Forskning
Udskriv Udskriv
Switch language
Region Hovedstaden - en del af Københavns Universitetshospital
Udgivet

Changes in subtypes of overt thyrotoxicosis and hypothyroidism following iodine fortification

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

DOI

  1. Sex differences in acromegaly at diagnosis: A nationwide cohort study and meta-analysis of the literature

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  2. Increased levels of inflammatory factors are associated with severity of polyneuropathy in type 1 diabetes

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  3. Reproductive Hormones During Pubertal Transition in Girls with Transient Thelarche

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  4. Phenotypic and genotypic features of a large kindred with a germline AIP variant

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  5. Thyrotoxicosis after iodine fortification. A 21-year Danish population-based study

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  1. Detection of illness worry in the general population: A specific item on illness rumination improves the Whiteley Index

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  2. Long-term Consequences of Undiagnosed Celiac Seropositivity

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  3. Cardiac Troponin I and Incident Stroke in European Cohorts: Insights From the BiomarCaRE Project

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

Vis graf over relationer

Objective: To investigate the impact of mandatory iodine fortification (IF) on the incidence of nosological subtypes of overt thyrotoxicosis and hypothyroidism. Design: We identified and scrutinized all possible new cases of overt thyrotoxicosis and hypothyroidism in an open cohort in Northern Jutland (n = 309 434; 1 January 1997) during the years 2014-2016. Individual medical history was evaluated to verify and detail the incidence of overt thyroid dysfunction and for classification into nosological subtypes. A number of cases were excluded during final verification due to spontaneous normalization of thyroid function, as they had no medical history suggesting a known condition, which could transiently affect thyroid function (subacute/silent thyroiditis, PPTD and iatrogenic thyroid dysfunction). An identical survey was conducted in 1997-2000 prior to mandatory IF of salt (13 µg/g) that was in effect from year 2001. Results: The standardized incidence rate (SIR) of verified overt thyrotoxicosis decreased markedly from 97.5/100 000/year in 1997-2000 to 48.8 in 2014-2016 (SIRR: 0.50 [95% CI: 0.45-0.56]). This was due to a distinct decrease in the SIR of multinodular toxic goitre (SIRR: 0.18 [0.15-0.23]), solitary toxic adenoma (SIRR: 0.26 [0.16-0.43]) and to a lesser degree Graves’ disease (SIRR: 0.67 [0.56-0.79]). SIR for overt hypothyroidism was unaltered by 2014-2016 (SIRR: 1.03 [0.87-1.22]). However, age distribution shifted with more young and fewer elderly cases of verified overt hypothyroidism. Conclusion: Mandatory IF caused a substantial reduction in SIR of verified overt thyrotoxicosis (especially of nodular origin) while avoiding an increase in SIR of verified overt hypothyroidism.

OriginalsprogEngelsk
TidsskriftClinical Endocrinology
Vol/bind91
Udgave nummer5
Sider (fra-til)652-659
Antal sider8
ISSN0300-0664
DOI
StatusUdgivet - nov. 2019

ID: 57798662