@article{9ee99c3b5b1a4e42aa7fbbdaeff54cc8,
title = "Changes in peripheral blood level of regulatory T cells in patients with malignant melanoma during treatment with dendritic cell vaccination and low-dose IL-2",
abstract = "In this study, changes in peripheral blood regulatory T cell (Treg) levels were evaluated in 46 progressive patients with melanoma treated with a dendritic cell-based vaccine and concomitant low-dose IFN-α and IL-2. The regulatory subset of CD4 T cells, characterized by CD25(high) , was prospectively analysed in fresh blood, and treatment-associated quantitative and qualitative changes were analysed. By the 4th vaccine, patients showed a marked increase in CD4+ CD25(high) T cell subset from 6% to 22% (P",
keywords = "Adult, Aged, Aged, 80 and over, Cancer Vaccines, Dendritic Cells, Female, Humans, Immunologic Factors, Interferon-alpha, Interleukin-2, Male, Melanoma, Middle Aged, Skin Neoplasms, T-Lymphocyte Subsets, T-Lymphocytes, Regulatory, Vaccination",
author = "J Bjoern and Brimnes, {M K} and Andersen, {M H} and Straten, {Per thor} and Svane, {I M}",
note = "{\textcopyright} 2011 The Authors. Scandinavian Journal of Immunology {\textcopyright} 2011 Blackwell Publishing Ltd.",
year = "2011",
doi = "10.1111/j.1365-3083.2010.02494.x",
language = "English",
volume = "73",
pages = "222--33",
journal = "Scandinavian Journal of Immunology",
issn = "0300-9475",
publisher = "Wiley-Blackwell Publishing Ltd",
number = "3",
}