Changes in EEG, systemic circulation and blood gas parameters following two or six aliquots of porcine surfactant

K. E. Lundstrøm*, G. Greisen

*Corresponding author af dette arbejde
29 Citationer (Scopus)

Abstract

Surfactant instillation often causes transient EEG suppression, the cause remaining unknown. To compare the timing of the EEG changes with the timing of the changes in blood gases and systemic circulation we compared two administration modes: 20 preterm infants were randomly assigned to receive the initial dose of surfactant divided into two or six aliquots. Heart rate, blood pressure and transcutaneous blood gases were measured continuously, while left ventricular output was estimated intermittently. No difference in blood gas response was found between the groups, whereas the circulatory changes occurred more gradually with six aliquots. EEG suppression was similar in the two groups and not related to the circulatory or the respiratory changes. Left ventricular output increased in all patients following surfactant instillation. We conclude that the EEG suppression is not directly related to alterations in blood gases or systemic circulation.

OriginalsprogEngelsk
TidsskriftActa Paediatrica, International Journal of Paediatrics
Vol/bind85
Udgave nummer6
Sider (fra-til)708-712
Antal sider5
ISSN0803-5253
DOI
StatusUdgivet - 1996

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