Forskning
Udskriv Udskriv
Switch language
Region Hovedstaden - en del af Københavns Universitetshospital
Udgivet

Changes in C-reactive protein, neopterin and lactoferrin differ after conservative and surgical weight loss in individuals with morbid obesity

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

DOI

  1. Biochemical abnormalities among patients referred for celiac disease antibody blood testing in a primary health care setting

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  2. Reduced levels of pulmonary surfactant in COVID-19 ARDS

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  3. Chronic inflammation markers and cytokine-specific autoantibodies in Danish blood donors with restless legs syndrome

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  4. Assessment of immunogenicity and drug activity in patient sera by flow-induced dispersion analysis

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  1. Surgical preparation and draping prior to induction of total intravenous anaesthesia

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  2. Mortality of older acutely admitted medical patients after early discharge from emergency departments: a nationwide cohort study

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  3. Genetic markers of abdominal obesity and weight loss after gastric bypass surgery

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  4. Commentary on "Predictors of Acute Kidney Injury After Hip Fracture in Older Adults"

    Publikation: Bidrag til tidsskriftKommentar/debatForskningpeer review

Vis graf over relationer

C-reactive protein, neopterin and lactoferrin are biomarkers of atherosclerotic disease. We aimed to assess changes in these biomarkers after conservative and surgical weight loss interventions in individuals with morbid obesity, to evaluate associations between biomarker changes and changes in body mass index and HbA1c, and to study associations between changes in the biomarkers. C-reactive protein, neopterin and lactoferrin were measured before and after conservative weight loss intervention and bariatric surgery. Data were analysed with mixed models. 137 individuals (mean age 43 years) were included. Body mass index decreased from 42.1 kg/m2 to 38.9 kg/m2 after the conservative intervention, and further to 30.5 kg/m2 after bariatric surgery. All biomarkers decreased after the conservative weight loss intervention. C-reactive protein and lactoferrin continued to decrease following bariatric surgery whereas neopterin remained stable. After adjustments for change in body mass index and HbA1c, all biomarkers decreased significantly after the conservative weight loss intervention, whereas none changed after bariatric surgery. There were no consistent correlations between changes in C-reactive protein, neopterin and lactoferrin. In conclusion, biomarkers of atherosclerosis decreased after weight loss interventions but had different trajectories. Neopterin, a marker related to atherosclerotic plaque stability, decreased after conservative weight loss but not following bariatric surgery.

OriginalsprogEngelsk
TidsskriftScientific Reports
Vol/bind9
Udgave nummer1
Sider (fra-til)17695
ISSN2045-2322
DOI
StatusUdgivet - 27 nov. 2019

ID: 59411984