TY - JOUR
T1 - Changes in cerebral blood flow after acetazolamide: an experimental study comparing near-infrared spectroscopy and SPECT
AU - Schytz, H W
AU - Wienecke, Troels
AU - Jensen, Lars Thorbjørn
AU - Selb, J
AU - Boas, D A
AU - Ashina, M
N1 - Keywords: Acetazolamide; Adolescent; Adult; Arterioles; Brain; Carbonic Anhydrase Inhibitors; Cerebrovascular Circulation; Female; Humans; Indocyanine Green; Injections, Intravenous; Male; Regional Blood Flow; Skin; Spectroscopy, Near-Infrared; Tomography, Emission-Computed, Single-Photon; Xenon Radioisotopes; Young Adult
PY - 2009
Y1 - 2009
N2 - BACKGROUND AND PURPOSE: It is important to find a reliable and bedside method, which can estimate the cerebral blood flow (CBF) of patients in clinical settings. Estimation of CBF by calculating a blood flow index (BFI) using continuous wave near-infrared spectroscopy (CW-NIRS) and indocyanine green (ICG) as an i.v. tracer has been proposed to be a feasible and promising method. To validate if the BFI method can detect relative changes in CBF we compared data with the established method (133)Xenon single photon emission computer tomography ((133)Xe-SPECT). METHODS: Ten healthy subjects were investigated before and after a bolus of acetazolamide. NIRS data were obtained using a multi source detector separation configuration in order to assess a corrected BFI (BFI(corr)) value, which attempts to eliminate contamination of skin blood flow. RESULTS: Data obtained showed no significant correlation between CBF changes measured by (133)Xe-SPECT and BFI(corr) (0.133, P = 0.732). After acetazolamide, a 49% increase in CBF was detected using the (133)Xe-SPECT method, whereas no changes in any ICG variables were observed after acetazolamide. CONCLUSION: The study shows that it is not possible to obtain reliable BFI data, which reflect changes in CBF after acetazolamide infusion, using the CW-NIRS and ICG method.
AB - BACKGROUND AND PURPOSE: It is important to find a reliable and bedside method, which can estimate the cerebral blood flow (CBF) of patients in clinical settings. Estimation of CBF by calculating a blood flow index (BFI) using continuous wave near-infrared spectroscopy (CW-NIRS) and indocyanine green (ICG) as an i.v. tracer has been proposed to be a feasible and promising method. To validate if the BFI method can detect relative changes in CBF we compared data with the established method (133)Xenon single photon emission computer tomography ((133)Xe-SPECT). METHODS: Ten healthy subjects were investigated before and after a bolus of acetazolamide. NIRS data were obtained using a multi source detector separation configuration in order to assess a corrected BFI (BFI(corr)) value, which attempts to eliminate contamination of skin blood flow. RESULTS: Data obtained showed no significant correlation between CBF changes measured by (133)Xe-SPECT and BFI(corr) (0.133, P = 0.732). After acetazolamide, a 49% increase in CBF was detected using the (133)Xe-SPECT method, whereas no changes in any ICG variables were observed after acetazolamide. CONCLUSION: The study shows that it is not possible to obtain reliable BFI data, which reflect changes in CBF after acetazolamide infusion, using the CW-NIRS and ICG method.
U2 - 10.1111/j.1468-1331.2008.02398.x
DO - 10.1111/j.1468-1331.2008.02398.x
M3 - Journal article
C2 - 19236469
SN - 1351-5101
VL - 16
SP - 461
EP - 467
JO - European Journal of Neurology
JF - European Journal of Neurology
IS - 4
ER -