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Changes in body water distribution during treatment with inhaled steroid in pre-school children

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@article{cef350751da04de5977280fcca3ef19d,
title = "Changes in body water distribution during treatment with inhaled steroid in pre-school children",
abstract = "PRIMARY OBJECTIVE: The study aimed to examine the changes in water distribution in the soft tissue during systemic steroid activity.RESEARCH DESIGN: A three-way cross-over, randomized, placebo-controlled, double-blind trial was used, including 4 weeks of fluticasone propionate pMDI 200 microg b.i.d. delivered via Babyhaler, budesonide pressurized metered dose inhaler (pMDI) 200 microg b.i.d. delivered via Nebuchamber and placebo. Spacers were primed before use. In total, 40 children aged 1-3 years, with mild intermittent asthma were included. Twenty-five of the children completed all three treatments. At the end of each treatment period body impedance and skin ultrasonography were measured.METHODS AND PROCEDURES: We measured changes in water content of the soft tissues by two methods. Skin ultrasonography was used to detect small changes in dermal water content, and bioelectrical impedance was used to assess body water content and distribution.MAIN OUTCOMES AND RESULTS: We found an increase in skin density of the shin from fluticasone as measured by ultrasonography (p = 0.01). There was a tendency for a consistent elevation of impedance parameters from active treatments compared to placebo although overall this effect was not statistically significant (0.1 < p < 0.2). However, sub-analyses indicated a significant effect on whole-body and leg impedance from budesonide treatment (p < 0.05).CONCLUSION: Decreased growth during inhaled steroid treatment seems to partly reflect generalized changes in body water.",
keywords = "Administration, Inhalation, Androstadienes, Asthma, Body Water, Bronchodilator Agents, Budesonide, Child, Preschool, Cross-Over Studies, Double-Blind Method, Electric Impedance, Female, Humans, Male, Skin",
author = "Heitmann, {B L} and Jacob Anh{\o}j and Bisgaard, {A M} and L Ward and H Bisgaard",
note = "Copyright 2004 Taylor and Francis Ltd.",
year = "2004",
month = "6",
day = "19",
doi = "10.1080/0301446042000208286",
language = "English",
volume = "31",
pages = "333--41",
journal = "Annals of Human Biology",
issn = "0301-4460",
publisher = "Informa Healthcare",
number = "3",

}

RIS

TY - JOUR

T1 - Changes in body water distribution during treatment with inhaled steroid in pre-school children

AU - Heitmann, B L

AU - Anhøj, Jacob

AU - Bisgaard, A M

AU - Ward, L

AU - Bisgaard, H

N1 - Copyright 2004 Taylor and Francis Ltd.

PY - 2004/6/19

Y1 - 2004/6/19

N2 - PRIMARY OBJECTIVE: The study aimed to examine the changes in water distribution in the soft tissue during systemic steroid activity.RESEARCH DESIGN: A three-way cross-over, randomized, placebo-controlled, double-blind trial was used, including 4 weeks of fluticasone propionate pMDI 200 microg b.i.d. delivered via Babyhaler, budesonide pressurized metered dose inhaler (pMDI) 200 microg b.i.d. delivered via Nebuchamber and placebo. Spacers were primed before use. In total, 40 children aged 1-3 years, with mild intermittent asthma were included. Twenty-five of the children completed all three treatments. At the end of each treatment period body impedance and skin ultrasonography were measured.METHODS AND PROCEDURES: We measured changes in water content of the soft tissues by two methods. Skin ultrasonography was used to detect small changes in dermal water content, and bioelectrical impedance was used to assess body water content and distribution.MAIN OUTCOMES AND RESULTS: We found an increase in skin density of the shin from fluticasone as measured by ultrasonography (p = 0.01). There was a tendency for a consistent elevation of impedance parameters from active treatments compared to placebo although overall this effect was not statistically significant (0.1 < p < 0.2). However, sub-analyses indicated a significant effect on whole-body and leg impedance from budesonide treatment (p < 0.05).CONCLUSION: Decreased growth during inhaled steroid treatment seems to partly reflect generalized changes in body water.

AB - PRIMARY OBJECTIVE: The study aimed to examine the changes in water distribution in the soft tissue during systemic steroid activity.RESEARCH DESIGN: A three-way cross-over, randomized, placebo-controlled, double-blind trial was used, including 4 weeks of fluticasone propionate pMDI 200 microg b.i.d. delivered via Babyhaler, budesonide pressurized metered dose inhaler (pMDI) 200 microg b.i.d. delivered via Nebuchamber and placebo. Spacers were primed before use. In total, 40 children aged 1-3 years, with mild intermittent asthma were included. Twenty-five of the children completed all three treatments. At the end of each treatment period body impedance and skin ultrasonography were measured.METHODS AND PROCEDURES: We measured changes in water content of the soft tissues by two methods. Skin ultrasonography was used to detect small changes in dermal water content, and bioelectrical impedance was used to assess body water content and distribution.MAIN OUTCOMES AND RESULTS: We found an increase in skin density of the shin from fluticasone as measured by ultrasonography (p = 0.01). There was a tendency for a consistent elevation of impedance parameters from active treatments compared to placebo although overall this effect was not statistically significant (0.1 < p < 0.2). However, sub-analyses indicated a significant effect on whole-body and leg impedance from budesonide treatment (p < 0.05).CONCLUSION: Decreased growth during inhaled steroid treatment seems to partly reflect generalized changes in body water.

KW - Administration, Inhalation

KW - Androstadienes

KW - Asthma

KW - Body Water

KW - Bronchodilator Agents

KW - Budesonide

KW - Child, Preschool

KW - Cross-Over Studies

KW - Double-Blind Method

KW - Electric Impedance

KW - Female

KW - Humans

KW - Male

KW - Skin

U2 - 10.1080/0301446042000208286

DO - 10.1080/0301446042000208286

M3 - Journal article

VL - 31

SP - 333

EP - 341

JO - Annals of Human Biology

JF - Annals of Human Biology

SN - 0301-4460

IS - 3

ER -

ID: 45753568