TY - JOUR
T1 - Change in global longitudinal strain following acute coronary syndrome and subsequent risk of heart failure
AU - Ravnkilde, Kirstine
AU - Skaarup, Kristoffer Grundtvig
AU - Grove, Gabriela Lladó
AU - Modin, Daniel
AU - Nielsen, Anne Bjerg
AU - Falsing, Mathilde Musoni
AU - Iversen, Allan Zeeberg
AU - Pedersen, Sune
AU - Fritz-Hansen, Thomas
AU - Galatius, Søren
AU - Jespersen, Thomas
AU - Shah, Amil
AU - Gislason, Gunnar
AU - Biering-Sørensen, Tor
N1 - © 2021. The Author(s), under exclusive licence to Springer Nature B.V.
PY - 2021/11
Y1 - 2021/11
N2 - Global Longitudinal Strain (GLS) is a well-established predictor of heart failure (HF) following acute coronary syndrome (ACS). We aim to investigate the prognostic value of GLS obtained at a follow-up consultation, as well as the change in GLS for long-term risk of incident HF. A total of 235 ACS patients had an echocardiogram performed immediately after percutaneous coronary intervention (PCI) and a follow-up echocardiogram (FUE) median 215 (IQR: 71; 878) days after the first echocardiogram. Endpoint was incident HF. Follow-up time after FUE was median 4.8 (IQR: 3.7; 5.6) years. Patients diagnosed with HF before FUE were excluded. Mean age was 63 ± 11 years and 77% were male. Baseline GLS was on average 12.7 ± 3.9%, FUE GLS was on average 13.5 ± 3.9% and mean improvement in GLS was 0.73 ± 3.68% between the 2 echocardiograms. A total of 57 (24%) patients suffered incident HF following the FUE. FUE GLS provided significantly higher prognostic information for risk of incident HF than ∆GLS when assessed by the C-statistics (C-statistics: 0.71 vs. 0.61, P = 0.021). Furthermore, after multivariable adjustments only FUE GLS [HR = 1.15, 95% CI (1.02; 1.29), P = 0.018, per 1% decrease] remained an independent predictor of incident HF. In patients with ACS, who do not develop HF before FUE, FUE GLS was an independent predictor of long-term risk of incident HF while ∆GLS was not.
AB - Global Longitudinal Strain (GLS) is a well-established predictor of heart failure (HF) following acute coronary syndrome (ACS). We aim to investigate the prognostic value of GLS obtained at a follow-up consultation, as well as the change in GLS for long-term risk of incident HF. A total of 235 ACS patients had an echocardiogram performed immediately after percutaneous coronary intervention (PCI) and a follow-up echocardiogram (FUE) median 215 (IQR: 71; 878) days after the first echocardiogram. Endpoint was incident HF. Follow-up time after FUE was median 4.8 (IQR: 3.7; 5.6) years. Patients diagnosed with HF before FUE were excluded. Mean age was 63 ± 11 years and 77% were male. Baseline GLS was on average 12.7 ± 3.9%, FUE GLS was on average 13.5 ± 3.9% and mean improvement in GLS was 0.73 ± 3.68% between the 2 echocardiograms. A total of 57 (24%) patients suffered incident HF following the FUE. FUE GLS provided significantly higher prognostic information for risk of incident HF than ∆GLS when assessed by the C-statistics (C-statistics: 0.71 vs. 0.61, P = 0.021). Furthermore, after multivariable adjustments only FUE GLS [HR = 1.15, 95% CI (1.02; 1.29), P = 0.018, per 1% decrease] remained an independent predictor of incident HF. In patients with ACS, who do not develop HF before FUE, FUE GLS was an independent predictor of long-term risk of incident HF while ∆GLS was not.
KW - Acute Coronary Syndrome/diagnostic imaging
KW - Aged
KW - Echocardiography
KW - Heart Failure/diagnostic imaging
KW - Humans
KW - Male
KW - Middle Aged
KW - Percutaneous Coronary Intervention/adverse effects
KW - Predictive Value of Tests
KW - Risk Factors
KW - Stroke Volume
KW - Ventricular Function, Left
UR - http://www.scopus.com/inward/record.url?scp=85107284557&partnerID=8YFLogxK
U2 - 10.1007/s10554-021-02296-y
DO - 10.1007/s10554-021-02296-y
M3 - Journal article
C2 - 34059976
VL - 37
SP - 3193
EP - 3202
JO - International Journal of Cardiovascular Imaging
JF - International Journal of Cardiovascular Imaging
SN - 1569-5794
IS - 11
ER -