Change in global longitudinal strain following acute coronary syndrome and subsequent risk of heart failure

Kirstine Ravnkilde, Kristoffer Grundtvig Skaarup, Gabriela Lladó Grove, Daniel Modin, Anne Bjerg Nielsen, Mathilde Musoni Falsing, Allan Zeeberg Iversen, Sune Pedersen, Thomas Fritz-Hansen, Søren Galatius, Thomas Jespersen, Amil Shah, Gunnar Gislason, Tor Biering-Sørensen

1 Citationer (Scopus)

Abstract

Global Longitudinal Strain (GLS) is a well-established predictor of heart failure (HF) following acute coronary syndrome (ACS). We aim to investigate the prognostic value of GLS obtained at a follow-up consultation, as well as the change in GLS for long-term risk of incident HF. A total of 235 ACS patients had an echocardiogram performed immediately after percutaneous coronary intervention (PCI) and a follow-up echocardiogram (FUE) median 215 (IQR: 71; 878) days after the first echocardiogram. Endpoint was incident HF. Follow-up time after FUE was median 4.8 (IQR: 3.7; 5.6) years. Patients diagnosed with HF before FUE were excluded. Mean age was 63 ± 11 years and 77% were male. Baseline GLS was on average 12.7 ± 3.9%, FUE GLS was on average 13.5 ± 3.9% and mean improvement in GLS was 0.73 ± 3.68% between the 2 echocardiograms. A total of 57 (24%) patients suffered incident HF following the FUE. FUE GLS provided significantly higher prognostic information for risk of incident HF than ∆GLS when assessed by the C-statistics (C-statistics: 0.71 vs. 0.61, P = 0.021). Furthermore, after multivariable adjustments only FUE GLS [HR = 1.15, 95% CI (1.02; 1.29), P = 0.018, per 1% decrease] remained an independent predictor of incident HF. In patients with ACS, who do not develop HF before FUE, FUE GLS was an independent predictor of long-term risk of incident HF while ∆GLS was not.

OriginalsprogEngelsk
TidsskriftThe international journal of cardiovascular imaging
Vol/bind37
Udgave nummer11
Sider (fra-til)3193-3202
Antal sider10
ISSN1569-5794
DOI
StatusUdgivet - nov. 2021

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