Harvard
D'Souza, M, Carlson, N, Fosbøl, E, Lamberts, M, Smedegaard, L, Nielsen, D, Torp-Pedersen, C, Gislason, G & Schou, M 2018, '
CHADS-VASc score and risk of thromboembolism and bleeding in patients with atrial fibrillation and recent cancer'
European journal of preventive cardiology, bind 25, nr. 6, s. 651-658.
https://doi.org/10.1177/2047487318759858
APA
D'Souza, M., Carlson, N., Fosbøl, E., Lamberts, M., Smedegaard, L., Nielsen, D., ... Schou, M. (2018).
CHADS-VASc score and risk of thromboembolism and bleeding in patients with atrial fibrillation and recent cancer.
European journal of preventive cardiology,
25(6), 651-658.
https://doi.org/10.1177/2047487318759858
CBE
MLA
Vancouver
Author
D'Souza, Maria ; Carlson, Nicholas ; Fosbøl, Emil ; Lamberts, Morten ; Smedegaard, Lærke ; Nielsen, Dorte ; Torp-Pedersen, Christian ; Gislason, Gunnar ; Schou, Morten. /
CHADS-VASc score and risk of thromboembolism and bleeding in patients with atrial fibrillation and recent cancer. I:
European journal of preventive cardiology. 2018 ; Bind 25, Nr. 6. s. 651-658.
Bibtex
@article{c4515c086c494ed7aca6fb064da7cf20,
title = "CHADS-VASc score and risk of thromboembolism and bleeding in patients with atrial fibrillation and recent cancer",
abstract = "Background Cancer may influence the risk of thromboembolism and bleeding associated with the CHA2DS2-VASc score. We examined the risk of thromboembolism and bleeding associated with the CHA2DS2-VASc score in atrial fibrillation patients with and without recent cancer. Methods and results Using nationwide registers all patients diagnosed with atrial fibrillation from 2000 to 2015 and not on oral anticoagulation or heparin therapy were included and followed for 2 years. Recent cancer was defined by a cancer diagnosis 5 years or fewer earlier. Risks of thromboembolism and bleeding were estimated in cumulative incidence curves and Cox regression models. We included 122,053 patients with incident atrial fibrillation, 12,014 (10{\%}) had recent cancer. The 2-year cumulative incidence of thromboembolism and bleeding in patients with versus without recent cancer was 1.7{\%} (95{\%} confidence interval (CI) 0.5-2.8) and 4.3{\%} (95{\%} CI 2.4-6.2) versus 1.2{\%} (95{\%} CI 0.9-1.5) and 1.7{\%} (95{\%} CI 1.4-2.0) for CHA2DS2-VASc score 0; 3.2{\%} (95{\%}CI 2.2-4.3) and 4.4{\%} (95{\%}CI 3.2-5.6) versus 1.8{\%} (95{\%}CI 1.6-2.1) and 3.0{\%} (95{\%} CI 2.7-3.3) for CHA2DS2-VASc score 1; and 7.1{\%} (95{\%} CI 6.6-7.7) and 6.8{\%} (95{\%} CI 6.3-7.2) versus 10.9{\%} (95{\%} CI 10.7-11.1) and 6.2{\%} (95{\%} CI 6.1-6.4) for CHA2DS2-VASc score 2 or greater. Although the CHA2DS2-VASc score was associated with thromboembolism and bleeding in both patients with and without cancer, the association differed between the groups for thromboembolism (test for interaction, p < 0.001) and bleeding (test for interaction, p < 0.001). Conclusion The association of the CHA2DS2-VASc score and risk of thromboembolism and bleeding differed between atrial fibrillation patients with and without recent cancer. Therefore, the CHA2DS2-VASc score should be used with caution in patients with recent cancer.",
author = "Maria D'Souza and Nicholas Carlson and Emil Fosb{\o}l and Morten Lamberts and L{\ae}rke Smedegaard and Dorte Nielsen and Christian Torp-Pedersen and Gunnar Gislason and Morten Schou",
year = "2018",
month = "4",
doi = "10.1177/2047487318759858",
language = "English",
volume = "25",
pages = "651--658",
journal = "European Journal of Cardiovascular Prevention and Rehabilitation",
issn = "2047-4873",
publisher = "Lippincott Williams & Wilkins",
number = "6",
}
RIS
TY - JOUR
T1 - CHADS-VASc score and risk of thromboembolism and bleeding in patients with atrial fibrillation and recent cancer
AU - D'Souza, Maria
AU - Carlson, Nicholas
AU - Fosbøl, Emil
AU - Lamberts, Morten
AU - Smedegaard, Lærke
AU - Nielsen, Dorte
AU - Torp-Pedersen, Christian
AU - Gislason, Gunnar
AU - Schou, Morten
PY - 2018/4
Y1 - 2018/4
N2 - Background Cancer may influence the risk of thromboembolism and bleeding associated with the CHA2DS2-VASc score. We examined the risk of thromboembolism and bleeding associated with the CHA2DS2-VASc score in atrial fibrillation patients with and without recent cancer. Methods and results Using nationwide registers all patients diagnosed with atrial fibrillation from 2000 to 2015 and not on oral anticoagulation or heparin therapy were included and followed for 2 years. Recent cancer was defined by a cancer diagnosis 5 years or fewer earlier. Risks of thromboembolism and bleeding were estimated in cumulative incidence curves and Cox regression models. We included 122,053 patients with incident atrial fibrillation, 12,014 (10%) had recent cancer. The 2-year cumulative incidence of thromboembolism and bleeding in patients with versus without recent cancer was 1.7% (95% confidence interval (CI) 0.5-2.8) and 4.3% (95% CI 2.4-6.2) versus 1.2% (95% CI 0.9-1.5) and 1.7% (95% CI 1.4-2.0) for CHA2DS2-VASc score 0; 3.2% (95%CI 2.2-4.3) and 4.4% (95%CI 3.2-5.6) versus 1.8% (95%CI 1.6-2.1) and 3.0% (95% CI 2.7-3.3) for CHA2DS2-VASc score 1; and 7.1% (95% CI 6.6-7.7) and 6.8% (95% CI 6.3-7.2) versus 10.9% (95% CI 10.7-11.1) and 6.2% (95% CI 6.1-6.4) for CHA2DS2-VASc score 2 or greater. Although the CHA2DS2-VASc score was associated with thromboembolism and bleeding in both patients with and without cancer, the association differed between the groups for thromboembolism (test for interaction, p < 0.001) and bleeding (test for interaction, p < 0.001). Conclusion The association of the CHA2DS2-VASc score and risk of thromboembolism and bleeding differed between atrial fibrillation patients with and without recent cancer. Therefore, the CHA2DS2-VASc score should be used with caution in patients with recent cancer.
AB - Background Cancer may influence the risk of thromboembolism and bleeding associated with the CHA2DS2-VASc score. We examined the risk of thromboembolism and bleeding associated with the CHA2DS2-VASc score in atrial fibrillation patients with and without recent cancer. Methods and results Using nationwide registers all patients diagnosed with atrial fibrillation from 2000 to 2015 and not on oral anticoagulation or heparin therapy were included and followed for 2 years. Recent cancer was defined by a cancer diagnosis 5 years or fewer earlier. Risks of thromboembolism and bleeding were estimated in cumulative incidence curves and Cox regression models. We included 122,053 patients with incident atrial fibrillation, 12,014 (10%) had recent cancer. The 2-year cumulative incidence of thromboembolism and bleeding in patients with versus without recent cancer was 1.7% (95% confidence interval (CI) 0.5-2.8) and 4.3% (95% CI 2.4-6.2) versus 1.2% (95% CI 0.9-1.5) and 1.7% (95% CI 1.4-2.0) for CHA2DS2-VASc score 0; 3.2% (95%CI 2.2-4.3) and 4.4% (95%CI 3.2-5.6) versus 1.8% (95%CI 1.6-2.1) and 3.0% (95% CI 2.7-3.3) for CHA2DS2-VASc score 1; and 7.1% (95% CI 6.6-7.7) and 6.8% (95% CI 6.3-7.2) versus 10.9% (95% CI 10.7-11.1) and 6.2% (95% CI 6.1-6.4) for CHA2DS2-VASc score 2 or greater. Although the CHA2DS2-VASc score was associated with thromboembolism and bleeding in both patients with and without cancer, the association differed between the groups for thromboembolism (test for interaction, p < 0.001) and bleeding (test for interaction, p < 0.001). Conclusion The association of the CHA2DS2-VASc score and risk of thromboembolism and bleeding differed between atrial fibrillation patients with and without recent cancer. Therefore, the CHA2DS2-VASc score should be used with caution in patients with recent cancer.
U2 - 10.1177/2047487318759858
DO - 10.1177/2047487318759858
M3 - Journal article
VL - 25
SP - 651
EP - 658
JO - European Journal of Cardiovascular Prevention and Rehabilitation
JF - European Journal of Cardiovascular Prevention and Rehabilitation
SN - 2047-4873
IS - 6
ER -