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Cervical cancer risk in women living with HIV across four continents: A multicohort study

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

Harvard

Rohner, E, Bütikofer, L, Schmidlin, K, Sengayi, M, Maskew, M, Giddy, J, Taghavi, K, Moore, RD, Goedert, JJ, Gill, MJ, Silverberg, MJ, D'Souza, G, Patel, P, Castilho, JL, Ross, J, Sohn, A, Bani-Sadr, F, Taylor, N, Paparizos, V, Bonnet, F, Verbon, A, Vehreschild, JJ, Post, FA, Sabin, C, Mocroft, A, Dronda, F, Obel, N, Grabar, S, Spagnuolo, V, Quiros-Roldan, E, Mussini, C, Miro, JM, Meyer, L, Hasse, B, Konopnicki, D, Roca, B, Barger, D, Clifford, GM, Franceschi, S, Egger, M & Bohlius, J 2020, 'Cervical cancer risk in women living with HIV across four continents: A multicohort study', International Journal of Cancer, bind 146, nr. 3, s. 601-609. https://doi.org/10.1002/ijc.32260

APA

Rohner, E., Bütikofer, L., Schmidlin, K., Sengayi, M., Maskew, M., Giddy, J., Taghavi, K., Moore, R. D., Goedert, J. J., Gill, M. J., Silverberg, M. J., D'Souza, G., Patel, P., Castilho, J. L., Ross, J., Sohn, A., Bani-Sadr, F., Taylor, N., Paparizos, V., ... Bohlius, J. (2020). Cervical cancer risk in women living with HIV across four continents: A multicohort study. International Journal of Cancer, 146(3), 601-609. https://doi.org/10.1002/ijc.32260

CBE

Rohner E, Bütikofer L, Schmidlin K, Sengayi M, Maskew M, Giddy J, Taghavi K, Moore RD, Goedert JJ, Gill MJ, Silverberg MJ, D'Souza G, Patel P, Castilho JL, Ross J, Sohn A, Bani-Sadr F, Taylor N, Paparizos V, Bonnet F, Verbon A, Vehreschild JJ, Post FA, Sabin C, Mocroft A, Dronda F, Obel N, Grabar S, Spagnuolo V, Quiros-Roldan E, Mussini C, Miro JM, Meyer L, Hasse B, Konopnicki D, Roca B, Barger D, Clifford GM, Franceschi S, Egger M, Bohlius J. 2020. Cervical cancer risk in women living with HIV across four continents: A multicohort study. International Journal of Cancer. 146(3):601-609. https://doi.org/10.1002/ijc.32260

MLA

Vancouver

Rohner E, Bütikofer L, Schmidlin K, Sengayi M, Maskew M, Giddy J o.a. Cervical cancer risk in women living with HIV across four continents: A multicohort study. International Journal of Cancer. 2020 feb 1;146(3):601-609. https://doi.org/10.1002/ijc.32260

Author

Rohner, Eliane ; Bütikofer, Lukas ; Schmidlin, Kurt ; Sengayi, Mazvita ; Maskew, Mhairi ; Giddy, Janet ; Taghavi, Katayoun ; Moore, Richard D ; Goedert, James J ; Gill, M John ; Silverberg, Michael J ; D'Souza, Gypsyamber ; Patel, Pragna ; Castilho, Jessica L ; Ross, Jeremy ; Sohn, Annette ; Bani-Sadr, Firouze ; Taylor, Ninon ; Paparizos, Vassilios ; Bonnet, Fabrice ; Verbon, Annelies ; Vehreschild, Jörg Janne ; Post, Frank A ; Sabin, Caroline ; Mocroft, Amanda ; Dronda, Fernando ; Obel, Niels ; Grabar, Sophie ; Spagnuolo, Vincenzo ; Quiros-Roldan, Eugenia ; Mussini, Cristina ; Miro, José M ; Meyer, Laurence ; Hasse, Barbara ; Konopnicki, Deborah ; Roca, Bernardino ; Barger, Diana ; Clifford, Gary M ; Franceschi, Silvia ; Egger, Matthias ; Bohlius, Julia. / Cervical cancer risk in women living with HIV across four continents : A multicohort study. I: International Journal of Cancer. 2020 ; Bind 146, Nr. 3. s. 601-609.

Bibtex

@article{e9ca9aa3a86342398fd700db705ee17b,
title = "Cervical cancer risk in women living with HIV across four continents: A multicohort study",
abstract = "We compared invasive cervical cancer (ICC) incidence rates in Europe, South Africa, Latin and North America among women living with HIV who initiated antiretroviral therapy (ART) between 1996 and 2014. We analyzed cohort data from the International Epidemiology Databases to Evaluate AIDS (IeDEA) and the Collaboration of Observational HIV Epidemiological Research in Europe (COHERE) in EuroCoord. We used flexible parametric survival models to determine regional ICC rates and risk factors for incident ICC. We included 64,231 women from 45 countries. During 320,141 person-years (pys), 356 incident ICC cases were diagnosed (Europe 164, South Africa 156, North America 19 and Latin America 17). Raw ICC incidence rates per 100,000 pys were 447 in South Africa (95% confidence interval [CI]: 382-523), 136 in Latin America (95% CI: 85-219), 76 in North America (95% CI: 48-119) and 66 in Europe (95% CI: 57-77). Compared to European women ICC rates at 5 years after ART initiation were more than double in Latin America (adjusted hazard ratio [aHR]: 2.43, 95% CI: 1.27-4.68) and 11 times higher in South Africa (aHR: 10.66, 95% CI: 6.73-16.88), but similar in North America (aHR: 0.79, 95% CI: 0.37-1.71). Overall, ICC rates increased with age (>50 years vs. 16-30 years, aHR: 1.57, 95% CI: 1.03-2.40) and lower CD4 cell counts at ART initiation (per 100 cell/μl decrease, aHR: 1.25, 95% CI: 1.15-1.36). Improving access to early ART initiation and effective cervical cancer screening in women living with HIV should be key parts of global efforts to reduce cancer-related health inequities.",
keywords = "Adolescent, Adult, Age Factors, Anti-Retroviral Agents/therapeutic use, CD4 Lymphocyte Count, Cross-Cultural Comparison, Early Detection of Cancer, Europe/epidemiology, Female, Follow-Up Studies, HIV Infections/blood, Health Status Disparities, Humans, Incidence, Latin America/epidemiology, Middle Aged, North America/epidemiology, Risk Factors, South Africa/epidemiology, Uterine Cervical Neoplasms/complications, Young Adult",
author = "Eliane Rohner and Lukas B{\"u}tikofer and Kurt Schmidlin and Mazvita Sengayi and Mhairi Maskew and Janet Giddy and Katayoun Taghavi and Moore, {Richard D} and Goedert, {James J} and Gill, {M John} and Silverberg, {Michael J} and Gypsyamber D'Souza and Pragna Patel and Castilho, {Jessica L} and Jeremy Ross and Annette Sohn and Firouze Bani-Sadr and Ninon Taylor and Vassilios Paparizos and Fabrice Bonnet and Annelies Verbon and Vehreschild, {J{\"o}rg Janne} and Post, {Frank A} and Caroline Sabin and Amanda Mocroft and Fernando Dronda and Niels Obel and Sophie Grabar and Vincenzo Spagnuolo and Eugenia Quiros-Roldan and Cristina Mussini and Miro, {Jos{\'e} M} and Laurence Meyer and Barbara Hasse and Deborah Konopnicki and Bernardino Roca and Diana Barger and Clifford, {Gary M} and Silvia Franceschi and Matthias Egger and Julia Bohlius",
note = "{\textcopyright} 2019 UICC.",
year = "2020",
month = feb,
day = "1",
doi = "10.1002/ijc.32260",
language = "English",
volume = "146",
pages = "601--609",
journal = "International Journal of Cancer",
issn = "0020-7136",
publisher = "JohnWiley & Sons, Inc",
number = "3",

}

RIS

TY - JOUR

T1 - Cervical cancer risk in women living with HIV across four continents

T2 - A multicohort study

AU - Rohner, Eliane

AU - Bütikofer, Lukas

AU - Schmidlin, Kurt

AU - Sengayi, Mazvita

AU - Maskew, Mhairi

AU - Giddy, Janet

AU - Taghavi, Katayoun

AU - Moore, Richard D

AU - Goedert, James J

AU - Gill, M John

AU - Silverberg, Michael J

AU - D'Souza, Gypsyamber

AU - Patel, Pragna

AU - Castilho, Jessica L

AU - Ross, Jeremy

AU - Sohn, Annette

AU - Bani-Sadr, Firouze

AU - Taylor, Ninon

AU - Paparizos, Vassilios

AU - Bonnet, Fabrice

AU - Verbon, Annelies

AU - Vehreschild, Jörg Janne

AU - Post, Frank A

AU - Sabin, Caroline

AU - Mocroft, Amanda

AU - Dronda, Fernando

AU - Obel, Niels

AU - Grabar, Sophie

AU - Spagnuolo, Vincenzo

AU - Quiros-Roldan, Eugenia

AU - Mussini, Cristina

AU - Miro, José M

AU - Meyer, Laurence

AU - Hasse, Barbara

AU - Konopnicki, Deborah

AU - Roca, Bernardino

AU - Barger, Diana

AU - Clifford, Gary M

AU - Franceschi, Silvia

AU - Egger, Matthias

AU - Bohlius, Julia

N1 - © 2019 UICC.

PY - 2020/2/1

Y1 - 2020/2/1

N2 - We compared invasive cervical cancer (ICC) incidence rates in Europe, South Africa, Latin and North America among women living with HIV who initiated antiretroviral therapy (ART) between 1996 and 2014. We analyzed cohort data from the International Epidemiology Databases to Evaluate AIDS (IeDEA) and the Collaboration of Observational HIV Epidemiological Research in Europe (COHERE) in EuroCoord. We used flexible parametric survival models to determine regional ICC rates and risk factors for incident ICC. We included 64,231 women from 45 countries. During 320,141 person-years (pys), 356 incident ICC cases were diagnosed (Europe 164, South Africa 156, North America 19 and Latin America 17). Raw ICC incidence rates per 100,000 pys were 447 in South Africa (95% confidence interval [CI]: 382-523), 136 in Latin America (95% CI: 85-219), 76 in North America (95% CI: 48-119) and 66 in Europe (95% CI: 57-77). Compared to European women ICC rates at 5 years after ART initiation were more than double in Latin America (adjusted hazard ratio [aHR]: 2.43, 95% CI: 1.27-4.68) and 11 times higher in South Africa (aHR: 10.66, 95% CI: 6.73-16.88), but similar in North America (aHR: 0.79, 95% CI: 0.37-1.71). Overall, ICC rates increased with age (>50 years vs. 16-30 years, aHR: 1.57, 95% CI: 1.03-2.40) and lower CD4 cell counts at ART initiation (per 100 cell/μl decrease, aHR: 1.25, 95% CI: 1.15-1.36). Improving access to early ART initiation and effective cervical cancer screening in women living with HIV should be key parts of global efforts to reduce cancer-related health inequities.

AB - We compared invasive cervical cancer (ICC) incidence rates in Europe, South Africa, Latin and North America among women living with HIV who initiated antiretroviral therapy (ART) between 1996 and 2014. We analyzed cohort data from the International Epidemiology Databases to Evaluate AIDS (IeDEA) and the Collaboration of Observational HIV Epidemiological Research in Europe (COHERE) in EuroCoord. We used flexible parametric survival models to determine regional ICC rates and risk factors for incident ICC. We included 64,231 women from 45 countries. During 320,141 person-years (pys), 356 incident ICC cases were diagnosed (Europe 164, South Africa 156, North America 19 and Latin America 17). Raw ICC incidence rates per 100,000 pys were 447 in South Africa (95% confidence interval [CI]: 382-523), 136 in Latin America (95% CI: 85-219), 76 in North America (95% CI: 48-119) and 66 in Europe (95% CI: 57-77). Compared to European women ICC rates at 5 years after ART initiation were more than double in Latin America (adjusted hazard ratio [aHR]: 2.43, 95% CI: 1.27-4.68) and 11 times higher in South Africa (aHR: 10.66, 95% CI: 6.73-16.88), but similar in North America (aHR: 0.79, 95% CI: 0.37-1.71). Overall, ICC rates increased with age (>50 years vs. 16-30 years, aHR: 1.57, 95% CI: 1.03-2.40) and lower CD4 cell counts at ART initiation (per 100 cell/μl decrease, aHR: 1.25, 95% CI: 1.15-1.36). Improving access to early ART initiation and effective cervical cancer screening in women living with HIV should be key parts of global efforts to reduce cancer-related health inequities.

KW - Adolescent

KW - Adult

KW - Age Factors

KW - Anti-Retroviral Agents/therapeutic use

KW - CD4 Lymphocyte Count

KW - Cross-Cultural Comparison

KW - Early Detection of Cancer

KW - Europe/epidemiology

KW - Female

KW - Follow-Up Studies

KW - HIV Infections/blood

KW - Health Status Disparities

KW - Humans

KW - Incidence

KW - Latin America/epidemiology

KW - Middle Aged

KW - North America/epidemiology

KW - Risk Factors

KW - South Africa/epidemiology

KW - Uterine Cervical Neoplasms/complications

KW - Young Adult

U2 - 10.1002/ijc.32260

DO - 10.1002/ijc.32260

M3 - Journal article

C2 - 31215037

VL - 146

SP - 601

EP - 609

JO - International Journal of Cancer

JF - International Journal of Cancer

SN - 0020-7136

IS - 3

ER -

ID: 59436291