Cerebrospinal fluid cytokines in geriatric patients with depressive disorders: A retrospective case-control study

Morten Brix Schou, Jeanette Brun Larsen, Astrid Kamilla Stunes, Sverre Georg Sæther

Abstract

Central nervous system inflammation might play a role in patients with depressive disorders. This hypothesis is supported by studies reporting increased cerebrospinal fluid levels of the inflammatory markers interleukin (IL)-6, IL-8 and tumor necrosis factor alpha (TNF-α) in patients with ongoing depression. In this case-control study, we aimed to examine whether these findings also applied to depressed patients in a geriatric population. Cerebrospinal fluid cytokine analyses were performed on 15 patients (age >60 years) with depressive disorders and 45 age- and sex matched controls (patients with headache or idiopathic facial palsy). IL-6, IL-8, IL-10, TNF-α, monocyte chemoattractant protein-1 and transforming growth factor beta 1 were included in the statistical analyses. Patients with depression had significantly lower cerebrospinal fluid levels of IL-6 as compared to controls ( p = 0.014) in the univariate analysis. The finding was, however, no longer statistically significant after correction for age and body mass index ( p = 0.097). Overall, this study indicates that the cytokines included in this study are not significantly altered in geriatric patients with depression. Future studies exploring cerebrospinal fluid cytokine levels should include corrections for possible confounding factors.

OriginalsprogEngelsk
Artikelnummer947605
TidsskriftFrontiers in Psychiatry
Vol/bind13
Sider (fra-til)947605
Antal sider7
ISSN1664-0640
DOI
StatusUdgivet - 2022
Udgivet eksterntJa

Fingeraftryk

Dyk ned i forskningsemnerne om 'Cerebrospinal fluid cytokines in geriatric patients with depressive disorders: A retrospective case-control study'. Sammen danner de et unikt fingeraftryk.

Citationsformater