Forskning
Udskriv Udskriv
Switch language
Region Hovedstaden - en del af Københavns Universitetshospital
Udgivet

Cerebrospinal fluid biomarkers of neurodegeneration, synaptic integrity, and astroglial activation across the clinical Alzheimer's disease spectrum

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

DOI

  1. APOE and dementia - resequencing and genotyping in 105,597 individuals

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  2. Shift work and incidence of dementia: A Danish Nurse Cohort study

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  3. Declining incidence of dementia: A national registry-based study over 20 years

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  4. Discovery and validation of plasma proteomic biomarkers relating to brain amyloid burden by SOMAscan assay

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  5. A new perspective for advanced positron emission tomography-based molecular imaging in neurodegenerative proteinopathies

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  1. Ceramides and phospholipids are downregulated with liraglutide treatment: results from the LiraFlame randomized controlled trial

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  2. Changes in the lipidome in type 1 diabetes following low carbohydrate diet: Post-hoc analysis of a randomized crossover trial

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  3. Cortical Frontoparietal Network Dysfunction in CHMP2B-Frontotemporal Dementia

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  4. Genome-wide association study of Alzheimer's disease CSF biomarkers in the EMIF-AD Multimodal Biomarker Discovery dataset

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  5. Gut microbiota profile and selected plasma metabolites in type 1 diabetes without and with stratification by albuminuria

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  • Isabelle Bos
  • Stephanie Vos
  • Frans Verhey
  • Philip Scheltens
  • Charlotte Teunissen
  • Sebastiaan Engelborghs
  • Kristel Sleegers
  • Giovanni Frisoni
  • Olivier Blin
  • Jill C Richardson
  • Régis Bordet
  • Magda Tsolaki
  • Julius Popp
  • Gwendoline Peyratout
  • Pablo Martinez-Lage
  • Mikel Tainta
  • Alberto Lleó
  • Peter Johannsen
  • Yvonne Freund-Levi
  • Lutz Frölich
  • Rik Vandenberghe
  • Sarah Westwood
  • Valerija Dobricic
  • Frederik Barkhof
  • Cristina Legido-Quigley
  • Lars Bertram
  • Simon Lovestone
  • Johannes Streffer
  • Ulf Andreasson
  • Kaj Blennow
  • Henrik Zetterberg
  • Pieter Jelle Visser
Vis graf over relationer

INTRODUCTION: We investigated relations between amyloid-β (Aβ) status, apolipoprotein E (APOE) ε4, and cognition, with cerebrospinal fluid markers of neurogranin (Ng), neurofilament light (NFL), YKL-40, and total tau (T-tau).

METHODS: We included 770 individuals with normal cognition, mild cognitive impairment, and Alzheimer's disease (AD)-type dementia from the EMIF-AD Multimodal Biomarker Discovery study. We tested the association of Ng, NFL, YKL-40, and T-tau with Aβ status (Aβ- vs. Aβ+), clinical diagnosis APOE ε4 carriership, baseline cognition, and change in cognition.

RESULTS: Ng and T-tau distinguished between Aβ+ from Aβ- individuals in each clinical group, whereas NFL and YKL-40 were associated with Aβ+ in nondemented individuals only. APOE ε4 carriership did not influence NFL, Ng, and YKL-40 in Aβ+ individuals. NFL was the best predictor of cognitive decline in Aβ+ individuals across the cognitive spectrum.

DISCUSSION: Axonal degeneration, synaptic dysfunction, astroglial activation, and altered tau metabolism are involved already in preclinical AD. NFL may be a useful prognostic marker.

OriginalsprogEngelsk
TidsskriftAlzheimer's & dementia : the journal of the Alzheimer's Association
Vol/bind15
Udgave nummer5
Sider (fra-til)644-654
Antal sider11
ISSN1552-5260
DOI
StatusUdgivet - 1 maj 2019

Bibliografisk note

Copyright © 2019 the Alzheimer's Association. All rights reserved.

ID: 56845185