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Cerebral serotonin transporter measurements with [11C]DASB: A review on acquisition and preprocessing across 21 PET centres

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Nørgaard, Martin ; Ganz, Melanie ; Svarer, Claus ; Feng, Ling ; Ichise, Masanori ; Lanzenberger, Rupert ; Lubberink, Mark ; Parsey, Ramin V ; Politis, Marios ; Rabiner, Eugenii A ; Slifstein, Mark ; Sossi, Vesna ; Suhara, Tetsuya ; Talbot, Peter S ; Turkheimer, Federico ; Strother, Stephen C ; Knudsen, Gitte M. / Cerebral serotonin transporter measurements with [11C]DASB : A review on acquisition and preprocessing across 21 PET centres. I: Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism. 2019 ; Bind 39, Nr. 2. s. 210-222.

Bibtex

@article{cea5ee36bcbb44b49309fc35a2d7dd49,
title = "Cerebral serotonin transporter measurements with [11C]DASB: A review on acquisition and preprocessing across 21 PET centres",
abstract = "Positron Emission Tomography (PET) imaging has become a prominent tool to capture the spatiotemporal distribution of neurotransmitters and receptors in the brain. The outcome of a PET study can, however, potentially be obscured by suboptimal and/or inconsistent choices made in complex processing pipelines required to reach a quantitative estimate of radioligand binding. Variations in subject selection, experimental design, data acquisition, preprocessing, and statistical analysis may lead to different outcomes and neurobiological interpretations. We here review the approaches used in 105 original research articles published by 21 different PET centres, using the tracer [11C]DASB for quantification of cerebral serotonin transporter binding, as an exemplary case. We highlight and quantify the impact of the remarkable variety of ways in which researchers are currently conducting their studies, while implicitly expecting generalizable results across research groups. Our review provides evidence that the foundation for a given choice of a preprocessing pipeline seems to be an overlooked aspect in modern PET neuroscience. Furthermore, we believe that a thorough testing of pipeline performance is necessary to produce reproducible research outcomes, avoiding biased results and allowing for better understanding of human brain function.",
author = "Martin N{\o}rgaard and Melanie Ganz and Claus Svarer and Ling Feng and Masanori Ichise and Rupert Lanzenberger and Mark Lubberink and Parsey, {Ramin V} and Marios Politis and Rabiner, {Eugenii A} and Mark Slifstein and Vesna Sossi and Tetsuya Suhara and Talbot, {Peter S} and Federico Turkheimer and Strother, {Stephen C} and Knudsen, {Gitte M}",
year = "2019",
month = "2",
doi = "10.1177/0271678X18770107",
language = "English",
volume = "39",
pages = "210--222",
journal = "Journal of Cerebral Blood Flow and Metabolism",
issn = "0271-678X",
publisher = "Nature Publishing Group",
number = "2",

}

RIS

TY - JOUR

T1 - Cerebral serotonin transporter measurements with [11C]DASB

T2 - A review on acquisition and preprocessing across 21 PET centres

AU - Nørgaard, Martin

AU - Ganz, Melanie

AU - Svarer, Claus

AU - Feng, Ling

AU - Ichise, Masanori

AU - Lanzenberger, Rupert

AU - Lubberink, Mark

AU - Parsey, Ramin V

AU - Politis, Marios

AU - Rabiner, Eugenii A

AU - Slifstein, Mark

AU - Sossi, Vesna

AU - Suhara, Tetsuya

AU - Talbot, Peter S

AU - Turkheimer, Federico

AU - Strother, Stephen C

AU - Knudsen, Gitte M

PY - 2019/2

Y1 - 2019/2

N2 - Positron Emission Tomography (PET) imaging has become a prominent tool to capture the spatiotemporal distribution of neurotransmitters and receptors in the brain. The outcome of a PET study can, however, potentially be obscured by suboptimal and/or inconsistent choices made in complex processing pipelines required to reach a quantitative estimate of radioligand binding. Variations in subject selection, experimental design, data acquisition, preprocessing, and statistical analysis may lead to different outcomes and neurobiological interpretations. We here review the approaches used in 105 original research articles published by 21 different PET centres, using the tracer [11C]DASB for quantification of cerebral serotonin transporter binding, as an exemplary case. We highlight and quantify the impact of the remarkable variety of ways in which researchers are currently conducting their studies, while implicitly expecting generalizable results across research groups. Our review provides evidence that the foundation for a given choice of a preprocessing pipeline seems to be an overlooked aspect in modern PET neuroscience. Furthermore, we believe that a thorough testing of pipeline performance is necessary to produce reproducible research outcomes, avoiding biased results and allowing for better understanding of human brain function.

AB - Positron Emission Tomography (PET) imaging has become a prominent tool to capture the spatiotemporal distribution of neurotransmitters and receptors in the brain. The outcome of a PET study can, however, potentially be obscured by suboptimal and/or inconsistent choices made in complex processing pipelines required to reach a quantitative estimate of radioligand binding. Variations in subject selection, experimental design, data acquisition, preprocessing, and statistical analysis may lead to different outcomes and neurobiological interpretations. We here review the approaches used in 105 original research articles published by 21 different PET centres, using the tracer [11C]DASB for quantification of cerebral serotonin transporter binding, as an exemplary case. We highlight and quantify the impact of the remarkable variety of ways in which researchers are currently conducting their studies, while implicitly expecting generalizable results across research groups. Our review provides evidence that the foundation for a given choice of a preprocessing pipeline seems to be an overlooked aspect in modern PET neuroscience. Furthermore, we believe that a thorough testing of pipeline performance is necessary to produce reproducible research outcomes, avoiding biased results and allowing for better understanding of human brain function.

U2 - 10.1177/0271678X18770107

DO - 10.1177/0271678X18770107

M3 - Journal article

VL - 39

SP - 210

EP - 222

JO - Journal of Cerebral Blood Flow and Metabolism

JF - Journal of Cerebral Blood Flow and Metabolism

SN - 0271-678X

IS - 2

ER -

ID: 57121492