Forskning
Udskriv Udskriv
Switch language
Region Hovedstaden - en del af Københavns Universitetshospital
Udgivet

Cerebral oxygenation and blood flow in normal term infants at rest measured by a hybrid near-infrared device (BabyLux)

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

DOI

  1. Serum, plasma and erythrocyte membrane lipidomes in infants fed formula supplemented with bovine milk fat globule membranes

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  2. NKG2D gene variation and susceptibility to viral bronchiolitis in childhood

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  3. Total brain, cortical and white matter volumes in children previously treated with glucocorticoids

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  4. Anogenital distance as a phenotypic signature through infancy

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  1. Neurodevelopmental disorder in children believed to have isolated mild ventriculomegaly prenatally

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  2. Hybrid PET/MRI imaging in healthy unsedated newborn infants with quantitative rCBF measurements using 15O-water PET

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  3. Infections seem to be more frequent before onset of pediatric multiple sclerosis: A Danish nationwide nested case-control study

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  4. Structural brain maturation differs between preterm and term piglets, whereas brain activity does not

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  • Bjørn Andresen
  • Agnese De Carli
  • Monica Fumagalli
  • Martina Giovannella
  • Turgut Durduran
  • Udo Michael Weigel
  • Davide Contini
  • Lorenzo Spinelli
  • Alessandro Torricelli
  • Gorm Greisen
Vis graf over relationer

BACKGROUND: The BabyLux device is a prototype optical neuro-monitor of cerebral oxygenation and blood flow for neonatology integrating time-resolved reflectance spectroscopy and diffuse correlation spectroscopy.

METHODS: Here we report the variability of six consecutive 30 s measurements performed in 27 healthy term infants at rest. Poor data quality excluded four infants.

RESULTS: Mean cerebral oxygenation was 59.6 ± 8.0%, with intra-subject standard deviation of 3.4%, that is, coefficient of variation (CV) of 5.7%. The inter-subject CV was 13.5%. Mean blood flow index was 2.7 × 10-8 ± 1.56 × 10-8 (cm2/s), with intra-subject CV of 27% and inter-subject CV of 56%. The variability in blood flow index was not reduced by the use of individual measures of tissue scattering, nor accompanied by a parallel variability in cerebral oxygenation.

CONCLUSION: The intra-subject variability for cerebral oxygenation variability was improved compared to spatially resolved spectroscopy devices, while for the blood flow index it was comparable to that of other modalities for estimating cerebral blood flow in newborn infants. Most importantly, the simultaneous measurement of oxygenation and flow allows for interpretation of the high inter-subject variability of cerebral blood flow as being due to error of measurement rather than to physiological instability.

OriginalsprogEngelsk
TidsskriftPediatric Research
Vol/bind86
Udgave nummer4
Sider (fra-til)515-521
Antal sider7
ISSN0031-3998
DOI
StatusUdgivet - okt. 2019

ID: 58060983