Cerebral oxygen metabolism and cerebral blood flow in man during light sleep (stage 2)

P L Madsen, J F Schmidt, S Holm, S Vorstrup, N A Lassen, Gordon Wildschiødtz

61 Citationer (Scopus)

Abstract

We measured cerebral blood flow (CBF) and cerebral metabolic rate of oxygen (CMRO2) during light sleep (stage 2) in 8 young healthy volunteers using the Kety-Schmidt technique with 133Xe as the inert gas. Measurements were performed during wakefulness and light sleep as verified by standard polysomnography. Unlike our previous study in man showing a highly significant 25% decrease in CMRO2 during deep sleep (stage 3-4) we found a modest but statistically significant decrease of 5% in CMRO2 during stage 2 sleep. Deep and light sleep are both characterized by an almost complete lack of mental activity. They differ in respect of arousal threshold as a stronger stimulus is required to awaken a subject from deep sleep as compared to light sleep. Our results suggest that during non-rapid eye movement sleep cerebral metabolism and thereby cerebral synaptic activity is correlated to cerebral readiness rather than to mental activity.
OriginalsprogEngelsk
TidsskriftBrain Research
Vol/bind557
Udgave nummer1-2
Sider (fra-til)217-20
Antal sider4
ISSN0006-8993
StatusUdgivet - 23 aug. 1991

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