Cerebral net exchange of large neutral amino acids after lipopolysaccharide infusion in healthy humans

Ronan Mg Berg; Sarah Taudorf; Damian M Bailey; Carsten Lundby; Fin Stolze Larsen; Bente Klarlund Pedersen; Kirsten Møller

doi:10.1186/cc8873

Cerebral net exchange of large neutral amino acids after lipopolysaccharide infusion in healthy humans

Ronan Mg Berg, Sarah Taudorf, Damian M Bailey, Carsten Lundby, Fin Stolze Larsen, Bente Klarlund Pedersen, Kirsten Møller

Afdeling for Hjerne- og Nervesygdomme

31 Citationer (Scopus)

Abstract

Alterations in circulating large neutral amino acids (LNAAs), leading to a decrease in the plasma ratio between branched-chain and aromatic amino acids (BCAA/AAA ratio), may be involved in sepsis-associated encephalopathy. We hypothesised that a decrease in the BCAA/AAA ratio occurs along with a net cerebral influx of the neurotoxic AAA phenylalanine in a human experimental model of systemic inflammation.

Originalsprog	Engelsk
Tidsskrift	Critical Care (Online Edition)
Vol/bind	14
Udgave nummer	1
Sider (fra-til)	R16
ISSN	1466-609X
DOI	https://doi.org/10.1186/cc8873
Status	Udgivet - 1 jan. 2010

Adgang til dokumentet

10.1186/cc8873

Citationsformater

@article{397f7c5169064a259388527b4a6cbffa,

title = "Cerebral net exchange of large neutral amino acids after lipopolysaccharide infusion in healthy humans",

abstract = "Alterations in circulating large neutral amino acids (LNAAs), leading to a decrease in the plasma ratio between branched-chain and aromatic amino acids (BCAA/AAA ratio), may be involved in sepsis-associated encephalopathy. We hypothesised that a decrease in the BCAA/AAA ratio occurs along with a net cerebral influx of the neurotoxic AAA phenylalanine in a human experimental model of systemic inflammation.",

author = "Berg, {Ronan Mg} and Sarah Taudorf and Bailey, {Damian M} and Carsten Lundby and Larsen, {Fin Stolze} and Pedersen, {Bente Klarlund} and Kirsten M{\o}ller",

year = "2010",

month = jan,

day = "1",

doi = "10.1186/cc8873",

language = "English",

volume = "14",

pages = "R16",

journal = "Critical Care (Online Edition)",

issn = "1466-609X",

publisher = "BioMed Central Ltd",

number = "1",

}

TY - JOUR

T1 - Cerebral net exchange of large neutral amino acids after lipopolysaccharide infusion in healthy humans

AU - Berg, Ronan Mg

AU - Taudorf, Sarah

AU - Bailey, Damian M

AU - Lundby, Carsten

AU - Larsen, Fin Stolze

AU - Pedersen, Bente Klarlund

AU - Møller, Kirsten

PY - 2010/1/1

Y1 - 2010/1/1

N2 - Alterations in circulating large neutral amino acids (LNAAs), leading to a decrease in the plasma ratio between branched-chain and aromatic amino acids (BCAA/AAA ratio), may be involved in sepsis-associated encephalopathy. We hypothesised that a decrease in the BCAA/AAA ratio occurs along with a net cerebral influx of the neurotoxic AAA phenylalanine in a human experimental model of systemic inflammation.

AB - Alterations in circulating large neutral amino acids (LNAAs), leading to a decrease in the plasma ratio between branched-chain and aromatic amino acids (BCAA/AAA ratio), may be involved in sepsis-associated encephalopathy. We hypothesised that a decrease in the BCAA/AAA ratio occurs along with a net cerebral influx of the neurotoxic AAA phenylalanine in a human experimental model of systemic inflammation.

U2 - 10.1186/cc8873

DO - 10.1186/cc8873

M3 - Journal article

C2 - 20149231

SN - 1466-609X

VL - 14

SP - R16

JO - Critical Care (Online Edition)

JF - Critical Care (Online Edition)

IS - 1

ER -

Cerebral net exchange of large neutral amino acids after lipopolysaccharide infusion in healthy humans

Abstract

Adgang til dokumentet

Fingeraftryk

Citationsformater