Cerebral Metabolic Rate of Glucose and Cognitive Tests in Long COVID Patients

Kamilla W Miskowiak; Johanne L Bech; Alexander Cuculiza Henriksen; Stine Johnsen; Daria Podlekareva; Lisbeth Marner

doi:10.3390/brainsci13010023

Cerebral Metabolic Rate of Glucose and Cognitive Tests in Long COVID Patients

Kamilla W Miskowiak, Johanne L Bech, Alexander Cuculiza Henriksen, Stine Johnsen, Daria Podlekareva, Lisbeth Marner

7 Citationer (Scopus)

Abstract

BACKGROUND: Common long-term sequelae after COVID-19 include fatigue and cognitive impairment. Although symptoms interfere with daily living, the underlying pathology is largely unknown. Previous studies report relative hypometabolism in frontal, limbic and cerebellar regions suggesting focal brain involvement. We aimed to determine whether absolute hypometabolism was present and correlated to same day standardized neurocognitive testing.

METHODS: Fourteen patients included from a long COVID clinic had cognitive testing and quantitative dynamic [18F]FDG PET of the brain on the same day to correlate cognitive function to metabolic glucose rate.

RESULTS: We found no hypometabolism in frontal, limbic and cerebellar regions in cognitively impaired relative to cognitive intact patients. In contrast, the cognitive impaired patients showed higher cerebellar metabolism (p = 0.03), which correlated with more severe deficits in working memory and executive function (p = 0.03).

CONCLUSIONS: Hypermetabolism in the cerebellum may reflect inefficient brain processing and play a role in cognitive impairments after COVID-19.

Originalsprog	Engelsk
Artikelnummer	23
Tidsskrift	Brain Sciences
Vol/bind	13
Udgave nummer	1
ISSN	2076-3425
DOI	https://doi.org/10.3390/brainsci13010023
Status	Udgivet - 22 dec. 2022

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title = "Cerebral Metabolic Rate of Glucose and Cognitive Tests in Long COVID Patients",

abstract = "BACKGROUND: Common long-term sequelae after COVID-19 include fatigue and cognitive impairment. Although symptoms interfere with daily living, the underlying pathology is largely unknown. Previous studies report relative hypometabolism in frontal, limbic and cerebellar regions suggesting focal brain involvement. We aimed to determine whether absolute hypometabolism was present and correlated to same day standardized neurocognitive testing.METHODS: Fourteen patients included from a long COVID clinic had cognitive testing and quantitative dynamic [18F]FDG PET of the brain on the same day to correlate cognitive function to metabolic glucose rate.RESULTS: We found no hypometabolism in frontal, limbic and cerebellar regions in cognitively impaired relative to cognitive intact patients. In contrast, the cognitive impaired patients showed higher cerebellar metabolism (p = 0.03), which correlated with more severe deficits in working memory and executive function (p = 0.03).CONCLUSIONS: Hypermetabolism in the cerebellum may reflect inefficient brain processing and play a role in cognitive impairments after COVID-19.",

author = "Miskowiak, {Kamilla W} and Bech, {Johanne L} and Henriksen, {Alexander Cuculiza} and Stine Johnsen and Daria Podlekareva and Lisbeth Marner",

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T1 - Cerebral Metabolic Rate of Glucose and Cognitive Tests in Long COVID Patients

AU - Miskowiak, Kamilla W

AU - Bech, Johanne L

AU - Henriksen, Alexander Cuculiza

AU - Johnsen, Stine

AU - Podlekareva, Daria

AU - Marner, Lisbeth

PY - 2022/12/22

Y1 - 2022/12/22

N2 - BACKGROUND: Common long-term sequelae after COVID-19 include fatigue and cognitive impairment. Although symptoms interfere with daily living, the underlying pathology is largely unknown. Previous studies report relative hypometabolism in frontal, limbic and cerebellar regions suggesting focal brain involvement. We aimed to determine whether absolute hypometabolism was present and correlated to same day standardized neurocognitive testing.METHODS: Fourteen patients included from a long COVID clinic had cognitive testing and quantitative dynamic [18F]FDG PET of the brain on the same day to correlate cognitive function to metabolic glucose rate.RESULTS: We found no hypometabolism in frontal, limbic and cerebellar regions in cognitively impaired relative to cognitive intact patients. In contrast, the cognitive impaired patients showed higher cerebellar metabolism (p = 0.03), which correlated with more severe deficits in working memory and executive function (p = 0.03).CONCLUSIONS: Hypermetabolism in the cerebellum may reflect inefficient brain processing and play a role in cognitive impairments after COVID-19.

AB - BACKGROUND: Common long-term sequelae after COVID-19 include fatigue and cognitive impairment. Although symptoms interfere with daily living, the underlying pathology is largely unknown. Previous studies report relative hypometabolism in frontal, limbic and cerebellar regions suggesting focal brain involvement. We aimed to determine whether absolute hypometabolism was present and correlated to same day standardized neurocognitive testing.METHODS: Fourteen patients included from a long COVID clinic had cognitive testing and quantitative dynamic [18F]FDG PET of the brain on the same day to correlate cognitive function to metabolic glucose rate.RESULTS: We found no hypometabolism in frontal, limbic and cerebellar regions in cognitively impaired relative to cognitive intact patients. In contrast, the cognitive impaired patients showed higher cerebellar metabolism (p = 0.03), which correlated with more severe deficits in working memory and executive function (p = 0.03).CONCLUSIONS: Hypermetabolism in the cerebellum may reflect inefficient brain processing and play a role in cognitive impairments after COVID-19.

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JO - Brain Sciences

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Cerebral Metabolic Rate of Glucose and Cognitive Tests in Long COVID Patients

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