Cerebral energy metabolism during induced mitochondrial dysfunction

T H Nielsen; Tao Bindslev; S M Pedersen; P Toft; N V Olsen; Carl-Henrik Nordström

doi:10.1111/j.1399-6576.2012.02783.x

Cerebral energy metabolism during induced mitochondrial dysfunction

T H Nielsen, Tao Bindslev, S M Pedersen, P Toft, N V Olsen, Carl-Henrik Nordström

36 Citationer (Scopus)

Abstract

In patients with traumatic brain injury as well as stroke, impaired cerebral oxidative energy metabolism may be an important factor contributing to the ultimate degree of tissue damage. We hypothesize that mitochondrial dysfunction can be diagnosed bedside by comparing the simultaneous changes in brain tissue oxygen tension (PbtO(2) ) and cerebral cytoplasmatic redox state. The study describes cerebral energy metabolism during mitochondrial dysfunction induced by sevoflurane in piglets.

Originalsprog	Engelsk
Tidsskrift	Acta Anaesthesiologica Scandinavica
Vol/bind	57
Udgave nummer	2
Sider (fra-til)	229-35
Antal sider	7
ISSN	0001-5172
DOI	https://doi.org/10.1111/j.1399-6576.2012.02783.x
Status	Udgivet - 2013

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10.1111/j.1399-6576.2012.02783.x

Citationsformater

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abstract = "In patients with traumatic brain injury as well as stroke, impaired cerebral oxidative energy metabolism may be an important factor contributing to the ultimate degree of tissue damage. We hypothesize that mitochondrial dysfunction can be diagnosed bedside by comparing the simultaneous changes in brain tissue oxygen tension (PbtO(2) ) and cerebral cytoplasmatic redox state. The study describes cerebral energy metabolism during mitochondrial dysfunction induced by sevoflurane in piglets.",

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AU - Nielsen, T H

AU - Bindslev, Tao

AU - Pedersen, S M

AU - Toft, P

AU - Olsen, N V

AU - Nordström, Carl-Henrik

PY - 2013

Y1 - 2013

N2 - In patients with traumatic brain injury as well as stroke, impaired cerebral oxidative energy metabolism may be an important factor contributing to the ultimate degree of tissue damage. We hypothesize that mitochondrial dysfunction can be diagnosed bedside by comparing the simultaneous changes in brain tissue oxygen tension (PbtO(2) ) and cerebral cytoplasmatic redox state. The study describes cerebral energy metabolism during mitochondrial dysfunction induced by sevoflurane in piglets.

AB - In patients with traumatic brain injury as well as stroke, impaired cerebral oxidative energy metabolism may be an important factor contributing to the ultimate degree of tissue damage. We hypothesize that mitochondrial dysfunction can be diagnosed bedside by comparing the simultaneous changes in brain tissue oxygen tension (PbtO(2) ) and cerebral cytoplasmatic redox state. The study describes cerebral energy metabolism during mitochondrial dysfunction induced by sevoflurane in piglets.

U2 - 10.1111/j.1399-6576.2012.02783.x

DO - 10.1111/j.1399-6576.2012.02783.x

M3 - Journal article

C2 - 23017022

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SP - 229

EP - 235

JO - Acta Anaesthesiologica Scandinavica

JF - Acta Anaesthesiologica Scandinavica

IS - 2

ER -

Cerebral energy metabolism during induced mitochondrial dysfunction

Abstract

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