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Central and cerebrovascular effects of leg crossing in humans with sympathetic failure

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DOI

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  • Mark P M Harms
  • Wouter Wieling
  • Willy N J M Colier
  • Jacques W M Lenders
  • Niels H Secher
  • Johannes J van Lieshout
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Leg crossing increases arterial pressure and combats symptomatic orthostatic hypotension in patients with sympathetic failure. This study compared the central and cerebrovascular effects of leg crossing in patients with sympathetic failure and healthy controls. We addressed the relationship between MCA Vmean (middle cerebral artery blood velocity; using transcranial Doppler ultrasound), frontal lobe oxygenation [O2Hb (oxyhaemoglobin)] and MAP (mean arterial pressure), CO (cardiac output) and TPR (total peripheral resistance) in six patients (aged 37-67 years; three women) and age- and gender-matched controls during leg crossing. In the patients, leg crossing increased MAP from 58 (42-79) to 72 (52-89) compared with 84 (70-95) to 90 (74-94) mmHg in the controls. MCA Vmean increased from 55 (38-77) to 63 (45-80) and from 56 (46-77) to 64 (46-80) cm/s respectively (P
OriginalsprogEngelsk
TidsskriftClinical science (London, England : 1979)
Vol/bind118
Udgave nummer9
Sider (fra-til)573-81
Antal sider9
DOI
StatusUdgivet - 1 maj 2010

ID: 32304403