Forskning
Udskriv Udskriv
Switch language
Region Hovedstaden - en del af Københavns Universitetshospital
Udgivet

Cellular homeostatic tension and force transmission measured in human engineered tendon

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  1. Day-to-Day Reliability of Nonlinear Methods to Assess Walking Dynamics

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  2. Assessment of intersegmental coordination of rats during walking at different speeds - Application of continuous relative phase

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  3. Day-to-day reliability of gait characteristics in rats

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  1. The influence of prolonged strength training upon muscle and fat in healthy and chronically diseased older adults

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  2. Associations between shoulder symptoms and concomitant pathology in patients with traumatic supraspinatus tears

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  3. The effect of 4 months exercise training on systemic biomarkers of cartilage and bone turnover in hip osteoarthritis patients

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  4. Early development of tendinopathy in humans: Sequence of pathological changes in structure and tissue turnover signaling

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

Vis graf over relationer

Tendons transmit contractile muscular force to bone to produce movement, and it is believed cells can generate endogenous forces on the extracellular matrix to maintain tissue homeostasis. However, little is known about the direct mechanical measurement of cell-matrix interaction in cell-generated human tendon constructs. In this study we examined if cell-generated force could be detected and quantified in engineered human tendon constructs, and if glycosaminoglycans (GAGs) contribute to tendon force transmission. Following de-tensioning of the tendon constructs it was possible to quantify an endogenous re-tensioning. Further, it was demonstrated that the endogenous re-tensioning response was markedly blunted after interference with the cytoskeleton (inhibiting non-muscle myosin-dependent cell contraction by blebbistatin), which confirmed that re-tensioning was cell generated. When the constructs were elongated and held at a constant length a stress relaxation response was quantified, and removing 27% of the GAG content of tendon did not alter the relaxation behavior, which indicates that GAGs do not play a meaningful role in force transmission within this system.

OriginalsprogEngelsk
TidsskriftJournal of Biomechanics
Vol/bind78
Sider (fra-til)161-165
Antal sider5
ISSN0021-9290
DOI
StatusUdgivet - 10 sep. 2018

ID: 56198902