TY - JOUR
T1 - Cell-free DNA and preoperative chemoradiotherapy for rectal cancer
T2 - a systematic review
AU - Boysen, Anders Kindberg
AU - Schou, Jakob Vasehus
AU - Spindler, Karen-Lise Garm
PY - 2019/7
Y1 - 2019/7
N2 - BACKGROUND: Preoperative chemoradiotherapy is the standard of care for patients with locally advanced rectal cancer, yet valid circulating biomarkers are lacking. We aimed at systematically reviewing the literature of cell-free DNA and locally advanced rectal cancer.METHODS: A systematic literature search was performed. We retrieved papers reporting a correlation between a clinical outcome and cell-free DNA for patients receiving chemoradiotherapy for locally advanced rectal cancer.RESULTS: We included nine studies of a total of 615 patients. Only single-arm studies were identified, analyzing either the total level of cell-free DNA or tumor-specific DNA. Despite differences in the methodology and outcomes, eight of the nine studies showed a correlation between cell-free DNA and a clinical outcome.CONCLUSIONS: Cell-free DNA might hold prognostic and predictive information for patients with locally advanced rectal cancer receiving preoperative chemoradiotherapy; although, firm conclusions are limited by the heterogeneity in this field.
AB - BACKGROUND: Preoperative chemoradiotherapy is the standard of care for patients with locally advanced rectal cancer, yet valid circulating biomarkers are lacking. We aimed at systematically reviewing the literature of cell-free DNA and locally advanced rectal cancer.METHODS: A systematic literature search was performed. We retrieved papers reporting a correlation between a clinical outcome and cell-free DNA for patients receiving chemoradiotherapy for locally advanced rectal cancer.RESULTS: We included nine studies of a total of 615 patients. Only single-arm studies were identified, analyzing either the total level of cell-free DNA or tumor-specific DNA. Despite differences in the methodology and outcomes, eight of the nine studies showed a correlation between cell-free DNA and a clinical outcome.CONCLUSIONS: Cell-free DNA might hold prognostic and predictive information for patients with locally advanced rectal cancer receiving preoperative chemoradiotherapy; although, firm conclusions are limited by the heterogeneity in this field.
KW - Biomarkers, Tumor/blood
KW - Cell-Free Nucleic Acids/blood
KW - Chemoradiotherapy
KW - Humans
KW - Preoperative Care
KW - Prognosis
KW - Rectal Neoplasms/blood
U2 - 10.1007/s12094-018-1997-y
DO - 10.1007/s12094-018-1997-y
M3 - Journal article
C2 - 30506526
SN - 1699-048X
VL - 21
SP - 874
EP - 880
JO - Clinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico
JF - Clinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico
IS - 7
ER -