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Region Hovedstaden - en del af Københavns Universitetshospital
Udgivet

Celiac disease: diagnosis and treatment

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

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  • Christian Lodberg Hvas
  • Michael Dam Jensen
  • Maria Christina Reimer
  • Lene Buhl Riis
  • Jüri Johannes Rumessen
  • Hanne Skovbjerg
  • Ane Teisner
  • Signe Wildt
Vis graf over relationer

This national clinical guideline approved by the Danish Society for Gastroenterology and Hepatology describes the diagnosis and treatment of celiac disease (CD) in adults. CD is a chronic immunemediated enteropathy of the small intestine triggered by the ingestion of gluten-containing proteins, which are found in wheat, rye, and barley. The disease prevalence is 0.5-1.0%, but CD remains under-diagnosed. The diagnosis relies on the demonstration of lymphocyte infiltration, crypt hyperplasia, and villous atrophy in duodenal biopsies. Serology, malabsorption, biochemical markers, and identification of specific HLA haplotypes may contribute to CD diagnosis. Classical CD presents with diarrhoea and weight loss, but non-classical CD with vague or extraintestinal symptoms is common. The treatment for CD is a lifelong gluten-free diet (GFD), which, in the majority of patients, normalises the small intestinal mucosa and absorption. Adherence to a GFD usually requires dietary advice from a clinical dietician. The monitoring of antibody levels and malabsorption markers is crucial during follow-up and allows for early treatment of disease complications. Important complications include osteoporosis, iron and vitamin deficiencies, and enteropathy-associated T-cell lymphoma.

OriginalsprogEngelsk
TidsskriftDanish Medical Bulletin (Online)
Vol/bind61
Udgave nummer4
ISSN1603-9629
StatusUdgivet - apr. 2015

ID: 45307981