@article{cac55a01209044ca84b19c09a51823a8,
title = "CD8+ T cell activation correlates with disease activity in clinically isolated syndromes and is regulated by interferon-beta treatment",
abstract = "An increased percentage of blood CD8+ T cells from patients with clinically isolated syndromes (CIS) suggestive of multiple sclerosis (MS) was found to express CD26 and CD69. The percentage of CD26 or CD69 positive CD8+ T cells was higher in patients with MRI evidence of disease dissemination in space or with active MRI lesions than in the remaining patients. Treatment of MS with interferon (IFN)-beta resulted in a decrease in the percentage of CD26 and CD71 positive CD8+ T cells and an increase in the percentage of CD8+ T cells that expressed interleukin (IL)-10 and IL-13. CD8+ T cell activation in MS may be linked to disease activity already at disease onset, and is regulated by treatment with IFN-beta.",
keywords = "Adult, Antigens, CD, Antigens, CD26, Antigens, Differentiation, T-Lymphocyte, Brain, CD8-Positive T-Lymphocytes, Female, Flow Cytometry, Humans, Immunologic Factors, Interferon-beta, Interleukin-10, Interleukin-13, Lymphocyte Activation, Lymphocyte Subsets, Male, Middle Aged, Multiple Sclerosis, Receptors, Transferrin",
author = "J Jensen and Sellebjerg, {Finn Thorup} and A Langkilde and Frederiksen, {Jette Lautrup Battistini}",
year = "2006",
doi = "10.1016/j.jneuroim.2006.06.024",
language = "English",
volume = "179",
pages = "163--72",
journal = "Journal of Neuroimmunology",
issn = "0165-5728",
publisher = "Elsevier BV",
number = "1-2",
}