TY - JOUR
T1 - CD3+CD8+CD161high Tc17 cells are depleted in HIV-infection
AU - Gaardbo, Julie Christine
AU - Hartling, Hans Jakob
AU - Thorsteinsson, Kristina
AU - Ullum, Henrik
AU - Nielsen, Susanne Dam
PY - 2012
Y1 - 2012
N2 - CD8+ Tc17 cells with pro-inflammatory properties have only recently been acknowledged, and Tc17 cells in HIV-infection are undescribed. CD3+CD8+CD161 Tc17 cells and the production of Interleukin-17 were examined in untreated and treated HIV-infected patients, HIV-HCV co-infected patients and healthy controls. Depletion of CD3+CD8+CD161 Tc17 cells and diminished production of Interleukin-17 in HIV-infected patients was found. The level of Tc17 cells was associated with the level of the CD4+ count in treated patients.
AB - CD8+ Tc17 cells with pro-inflammatory properties have only recently been acknowledged, and Tc17 cells in HIV-infection are undescribed. CD3+CD8+CD161 Tc17 cells and the production of Interleukin-17 were examined in untreated and treated HIV-infected patients, HIV-HCV co-infected patients and healthy controls. Depletion of CD3+CD8+CD161 Tc17 cells and diminished production of Interleukin-17 in HIV-infected patients was found. The level of Tc17 cells was associated with the level of the CD4+ count in treated patients.
U2 - 10.1097/QAD.0b013e32835b8cb3
DO - 10.1097/QAD.0b013e32835b8cb3
M3 - Journal article
C2 - 23135168
SN - 0269-9370
VL - 27
SP - 659
EP - 662
JO - AIDS
JF - AIDS
IS - 4
ER -