Causal relationship between obesity and vitamin D status: bi-directional Mendelian randomization analysis of multiple cohorts

Karani S Vimaleswaran; Diane J Berry; Chen Lu; Emmi Tikkanen; Stefan Pilz; Linda T Hiraki; Jason D Cooper; Zari Dastani; Rui Li; Denise K Houston; Andrew R Wood; Karl Michaëlsson; Liesbeth Vandenput; Lina Zgaga; Laura M Yerges-Armstrong; Mark I McCarthy; Josée Dupuis; Marika Kaakinen; Marcus E Kleber; Karen Jameson; Nigel Arden; Olli Raitakari; Jorma Viikari; Kurt K Lohman; Luigi Ferrucci; Håkan Melhus; Erik Ingelsson; Liisa Byberg; Lars Solskov Lind; Mattias Lorentzon; Veikko Salomaa; Harry Campbell; Malcolm Dunlop; Braxton D Mitchell; Karl-Heinz Herzig; Anneli Pouta; Anna-Liisa Hartikainen; Elizabeth A Streeten; Evropi Theodoratou; Antti Jula; Nicholas J Wareham; Claes Ohlsson; Timothy M Frayling; Stephen B Kritchevsky; Timothy D Spector; J Brent Richards; Terho Lehtimäki; Willem H Ouwehand; Peter Kraft; Cyrus Cooper; Genetic Investigation of Anthropometric Traits-GIANT Consortium

doi:10.1371/journal.pmed.1001383

Causal relationship between obesity and vitamin D status: bi-directional Mendelian randomization analysis of multiple cohorts

Karani S Vimaleswaran, Diane J Berry, Chen Lu, Emmi Tikkanen, Stefan Pilz, Linda T Hiraki, Jason D Cooper, Zari Dastani, Rui Li, Denise K Houston, Andrew R Wood, Karl Michaëlsson, Liesbeth Vandenput, Lina Zgaga, Laura M Yerges-Armstrong, Mark I McCarthy, Josée Dupuis, Marika Kaakinen, Marcus E Kleber, Karen JamesonNigel Arden, Olli Raitakari, Jorma Viikari, Kurt K Lohman, Luigi Ferrucci, Håkan Melhus, Erik Ingelsson, Liisa Byberg, Lars Solskov Lind, Mattias Lorentzon, Veikko Salomaa, Harry Campbell, Malcolm Dunlop, Braxton D Mitchell, Karl-Heinz Herzig, Anneli Pouta, Anna-Liisa Hartikainen, Elizabeth A Streeten, Evropi Theodoratou, Antti Jula, Nicholas J Wareham, Claes Ohlsson, Timothy M Frayling, Stephen B Kritchevsky, Timothy D Spector, J Brent Richards, Terho Lehtimäki, Willem H Ouwehand, Peter Kraft, Cyrus Cooper, Genetic Investigation of Anthropometric Traits-GIANT Consortium

804 Citationer (Scopus)

Abstract

Obesity is associated with vitamin D deficiency, and both are areas of active public health concern. We explored the causality and direction of the relationship between body mass index (BMI) and 25-hydroxyvitamin D [25(OH)D] using genetic markers as instrumental variables (IVs) in bi-directional Mendelian randomization (MR) analysis.

Originalsprog	Engelsk
Tidsskrift	PLOS Medicine
Vol/bind	10
Udgave nummer	2
Sider (fra-til)	e1001383
ISSN	1549-1676
DOI	https://doi.org/10.1371/journal.pmed.1001383
Status	Udgivet - 2013

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10.1371/journal.pmed.1001383

Citationsformater

Vimaleswaran, K. S., Berry, D. J., Lu, C., Tikkanen, E., Pilz, S., Hiraki, L. T., Cooper, J. D., Dastani, Z., Li, R., Houston, D. K., Wood, A. R., Michaëlsson, K., Vandenput, L., Zgaga, L., Yerges-Armstrong, L. M., McCarthy, M. I., Dupuis, J., Kaakinen, M., Kleber, M. E., ... Genetic Investigation of Anthropometric Traits-GIANT Consortium (2013). Causal relationship between obesity and vitamin D status: bi-directional Mendelian randomization analysis of multiple cohorts. PLOS Medicine, 10(2), e1001383. https://doi.org/10.1371/journal.pmed.1001383

Vimaleswaran, KS, Berry, DJ, Lu, C, Tikkanen, E, Pilz, S, Hiraki, LT, Cooper, JD, Dastani, Z, Li, R, Houston, DK, Wood, AR, Michaëlsson, K, Vandenput, L, Zgaga, L, Yerges-Armstrong, LM, McCarthy, MI, Dupuis, J, Kaakinen, M, Kleber, ME, Jameson, K, Arden, N, Raitakari, O, Viikari, J, Lohman, KK, Ferrucci, L, Melhus, H, Ingelsson, E, Byberg, L, Lind, LS, Lorentzon, M, Salomaa, V, Campbell, H, Dunlop, M, Mitchell, BD, Herzig, K-H, Pouta, A, Hartikainen, A-L, Streeten, EA, Theodoratou, E, Jula, A, Wareham, NJ, Ohlsson, C, Frayling, TM, Kritchevsky, SB, Spector, TD, Richards, JB, Lehtimäki, T, Ouwehand, WH, Kraft, P, Cooper, C & Genetic Investigation of Anthropometric Traits-GIANT Consortium 2013, 'Causal relationship between obesity and vitamin D status: bi-directional Mendelian randomization analysis of multiple cohorts', PLOS Medicine, bind 10, nr. 2, s. e1001383. https://doi.org/10.1371/journal.pmed.1001383

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title = "Causal relationship between obesity and vitamin D status: bi-directional Mendelian randomization analysis of multiple cohorts",

abstract = "Obesity is associated with vitamin D deficiency, and both are areas of active public health concern. We explored the causality and direction of the relationship between body mass index (BMI) and 25-hydroxyvitamin D [25(OH)D] using genetic markers as instrumental variables (IVs) in bi-directional Mendelian randomization (MR) analysis.",

keywords = "Adult, Aged, Aged, 80 and over, Biological Markers, Body Mass Index, Europe, European Continental Ancestry Group, Evidence-Based Medicine, Female, Genetic Predisposition to Disease, Humans, Linear Models, Male, Mendelian Randomization Analysis, Middle Aged, Multivariate Analysis, North America, Obesity, Phenotype, Polymorphism, Single Nucleotide, Risk Assessment, Risk Factors, Vitamin D, Vitamin D Deficiency",

author = "Vimaleswaran, {Karani S} and Berry, {Diane J} and Chen Lu and Emmi Tikkanen and Stefan Pilz and Hiraki, {Linda T} and Cooper, {Jason D} and Zari Dastani and Rui Li and Houston, {Denise K} and Wood, {Andrew R} and Karl Micha{\"e}lsson and Liesbeth Vandenput and Lina Zgaga and Yerges-Armstrong, {Laura M} and McCarthy, {Mark I} and Jos{\'e}e Dupuis and Marika Kaakinen and Kleber, {Marcus E} and Karen Jameson and Nigel Arden and Olli Raitakari and Jorma Viikari and Lohman, {Kurt K} and Luigi Ferrucci and H{\aa}kan Melhus and Erik Ingelsson and Liisa Byberg and Lind, {Lars Solskov} and Mattias Lorentzon and Veikko Salomaa and Harry Campbell and Malcolm Dunlop and Mitchell, {Braxton D} and Karl-Heinz Herzig and Anneli Pouta and Anna-Liisa Hartikainen and Streeten, {Elizabeth A} and Evropi Theodoratou and Antti Jula and Wareham, {Nicholas J} and Claes Ohlsson and Frayling, {Timothy M} and Kritchevsky, {Stephen B} and Spector, {Timothy D} and Richards, {J Brent} and Terho Lehtim{\"a}ki and Ouwehand, {Willem H} and Peter Kraft and Cyrus Cooper and {Genetic Investigation of Anthropometric Traits-GIANT Consortium}",

year = "2013",

doi = "10.1371/journal.pmed.1001383",

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T1 - Causal relationship between obesity and vitamin D status

T2 - bi-directional Mendelian randomization analysis of multiple cohorts

AU - Vimaleswaran, Karani S

AU - Berry, Diane J

AU - Lu, Chen

AU - Tikkanen, Emmi

AU - Pilz, Stefan

AU - Hiraki, Linda T

AU - Cooper, Jason D

AU - Dastani, Zari

AU - Li, Rui

AU - Houston, Denise K

AU - Wood, Andrew R

AU - Michaëlsson, Karl

AU - Vandenput, Liesbeth

AU - Zgaga, Lina

AU - Yerges-Armstrong, Laura M

AU - McCarthy, Mark I

AU - Dupuis, Josée

AU - Kaakinen, Marika

AU - Kleber, Marcus E

AU - Jameson, Karen

AU - Arden, Nigel

AU - Raitakari, Olli

AU - Viikari, Jorma

AU - Lohman, Kurt K

AU - Ferrucci, Luigi

AU - Melhus, Håkan

AU - Ingelsson, Erik

AU - Byberg, Liisa

AU - Lind, Lars Solskov

AU - Lorentzon, Mattias

AU - Salomaa, Veikko

AU - Campbell, Harry

AU - Dunlop, Malcolm

AU - Mitchell, Braxton D

AU - Herzig, Karl-Heinz

AU - Pouta, Anneli

AU - Hartikainen, Anna-Liisa

AU - Streeten, Elizabeth A

AU - Theodoratou, Evropi

AU - Jula, Antti

AU - Wareham, Nicholas J

AU - Ohlsson, Claes

AU - Frayling, Timothy M

AU - Kritchevsky, Stephen B

AU - Spector, Timothy D

AU - Richards, J Brent

AU - Lehtimäki, Terho

AU - Ouwehand, Willem H

AU - Kraft, Peter

AU - Cooper, Cyrus

AU - Genetic Investigation of Anthropometric Traits-GIANT Consortium

PY - 2013

Y1 - 2013

N2 - Obesity is associated with vitamin D deficiency, and both are areas of active public health concern. We explored the causality and direction of the relationship between body mass index (BMI) and 25-hydroxyvitamin D [25(OH)D] using genetic markers as instrumental variables (IVs) in bi-directional Mendelian randomization (MR) analysis.

AB - Obesity is associated with vitamin D deficiency, and both are areas of active public health concern. We explored the causality and direction of the relationship between body mass index (BMI) and 25-hydroxyvitamin D [25(OH)D] using genetic markers as instrumental variables (IVs) in bi-directional Mendelian randomization (MR) analysis.

KW - Adult

KW - Aged

KW - Aged, 80 and over

KW - Biological Markers

KW - Body Mass Index

KW - Europe

KW - European Continental Ancestry Group

KW - Evidence-Based Medicine

KW - Female

KW - Genetic Predisposition to Disease

KW - Humans

KW - Linear Models

KW - Male

KW - Mendelian Randomization Analysis

KW - Middle Aged

KW - Multivariate Analysis

KW - North America

KW - Obesity

KW - Phenotype

KW - Polymorphism, Single Nucleotide

KW - Risk Assessment

KW - Risk Factors

KW - Vitamin D

KW - Vitamin D Deficiency

U2 - 10.1371/journal.pmed.1001383

DO - 10.1371/journal.pmed.1001383

M3 - Journal article

C2 - 23393431

SN - 1549-1676

VL - 10

SP - e1001383

JO - PLOS Medicine

JF - PLOS Medicine

IS - 2

ER -

Causal relationship between obesity and vitamin D status: bi-directional Mendelian randomization analysis of multiple cohorts

Abstract

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