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Catch-up growth occurs after diarrhea in early childhood

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Childhood Malnutrition and Infection Network ; Fischer, Thea Kølsen. / Catch-up growth occurs after diarrhea in early childhood. I: The Journal of Nutrition. 2014 ; Bind 144, Nr. 6. s. 965-71.

Bibtex

@article{ecef7f87b1a74970b687ab33e0e185db,
title = "Catch-up growth occurs after diarrhea in early childhood",
abstract = "Diarrhea and linear growth faltering continue to burden low-income countries and are among the most important contributors to poor health during early childhood. Diarrhea is thought to adversely affect linear growth, but catch-up growth can occur if no additional insults are experienced. We sought to characterize catch-up growth in relation to diarrhea burden in a multisite dataset of 1007 children. Using longitudinal anthropometry and diarrheal surveillance data from 7 cohort studies in 4 countries, we examined the relation between diarrhea prevalence and growth in 3- to 6-mo periods using linear mixed-effect models. Growth during each period was calculated as a function of age using linear splines. We incorporated the longitudinal prevalence of diarrhea in both current and previous periods into the model. Diarrhea during the current period was associated with slower linear and ponderal growth. Faster (catch-up) growth in length was observed in children with no diarrhea in age groups immediately after an age group in which diarrhea was experienced [age group >6-12 mo: 0.03 mm/mo for each percentage diarrhea prevalence in the previous period (95{\%} CI: 0.007, 0.06) relative to 11.3 mm/mo mean growth rate; age group >12-18 mo: 0.04 mm/mo (95{\%} CI: 0.02, 0.06) relative to 8.9 mm/mo mean growth rate; age group >18-24 mo: 0.04 mm/mo (95{\%} CI: 0.003, 0.09) relative to 7.9 mm/mo mean growth rate]. The associations were stronger in boys than in girls when separate models were run. Similar results were observed when weight was the outcome variable. When diarrheal episodes are followed by diarrhea-free periods in the first 2 y of life, catch-up growth is observed that may allow children to regain their original trajectories. The finding of a greater effect of diarrhea on linear growth in boys than in girls was unexpected and requires additional study. Diarrhea burdens are high throughout the first 2 y of life in these study sites, therefore reducing the likelihood of catch-up growth. Extending diarrhea-free periods may increase the likelihood of catch-up growth and decrease the prevalence of stunting.",
keywords = "Body Height, Child Development, Child, Preschool, Cohort Studies, Diarrhea/complications, Female, Growth Disorders/epidemiology, Humans, Infant, Longitudinal Studies, Male, Prevalence, Reference Values, Weight Gain/physiology",
author = "Richard, {Stephanie A} and Black, {Robert E} and Gilman, {Robert H} and Guerrant, {Richard L} and Gagandeep Kang and Lanata, {Claudio F} and K{\aa}re M{\o}lbak and Rasmussen, {Zeba A} and Sack, {R Bradley} and Palle Valentiner-Branth and William Checkley and {Childhood Malnutrition and Infection Network} and Fischer, {Thea K{\o}lsen}",
note = "{\circledC} 2014 American Society for Nutrition.",
year = "2014",
month = "6",
doi = "10.3945/jn.113.187161",
language = "English",
volume = "144",
pages = "965--71",
journal = "The Journal of Nutrition",
issn = "0022-3166",
publisher = "American Society for Nutrition",
number = "6",

}

RIS

TY - JOUR

T1 - Catch-up growth occurs after diarrhea in early childhood

AU - Richard, Stephanie A

AU - Black, Robert E

AU - Gilman, Robert H

AU - Guerrant, Richard L

AU - Kang, Gagandeep

AU - Lanata, Claudio F

AU - Mølbak, Kåre

AU - Rasmussen, Zeba A

AU - Sack, R Bradley

AU - Valentiner-Branth, Palle

AU - Checkley, William

AU - Childhood Malnutrition and Infection Network

A2 - Fischer, Thea Kølsen

N1 - © 2014 American Society for Nutrition.

PY - 2014/6

Y1 - 2014/6

N2 - Diarrhea and linear growth faltering continue to burden low-income countries and are among the most important contributors to poor health during early childhood. Diarrhea is thought to adversely affect linear growth, but catch-up growth can occur if no additional insults are experienced. We sought to characterize catch-up growth in relation to diarrhea burden in a multisite dataset of 1007 children. Using longitudinal anthropometry and diarrheal surveillance data from 7 cohort studies in 4 countries, we examined the relation between diarrhea prevalence and growth in 3- to 6-mo periods using linear mixed-effect models. Growth during each period was calculated as a function of age using linear splines. We incorporated the longitudinal prevalence of diarrhea in both current and previous periods into the model. Diarrhea during the current period was associated with slower linear and ponderal growth. Faster (catch-up) growth in length was observed in children with no diarrhea in age groups immediately after an age group in which diarrhea was experienced [age group >6-12 mo: 0.03 mm/mo for each percentage diarrhea prevalence in the previous period (95% CI: 0.007, 0.06) relative to 11.3 mm/mo mean growth rate; age group >12-18 mo: 0.04 mm/mo (95% CI: 0.02, 0.06) relative to 8.9 mm/mo mean growth rate; age group >18-24 mo: 0.04 mm/mo (95% CI: 0.003, 0.09) relative to 7.9 mm/mo mean growth rate]. The associations were stronger in boys than in girls when separate models were run. Similar results were observed when weight was the outcome variable. When diarrheal episodes are followed by diarrhea-free periods in the first 2 y of life, catch-up growth is observed that may allow children to regain their original trajectories. The finding of a greater effect of diarrhea on linear growth in boys than in girls was unexpected and requires additional study. Diarrhea burdens are high throughout the first 2 y of life in these study sites, therefore reducing the likelihood of catch-up growth. Extending diarrhea-free periods may increase the likelihood of catch-up growth and decrease the prevalence of stunting.

AB - Diarrhea and linear growth faltering continue to burden low-income countries and are among the most important contributors to poor health during early childhood. Diarrhea is thought to adversely affect linear growth, but catch-up growth can occur if no additional insults are experienced. We sought to characterize catch-up growth in relation to diarrhea burden in a multisite dataset of 1007 children. Using longitudinal anthropometry and diarrheal surveillance data from 7 cohort studies in 4 countries, we examined the relation between diarrhea prevalence and growth in 3- to 6-mo periods using linear mixed-effect models. Growth during each period was calculated as a function of age using linear splines. We incorporated the longitudinal prevalence of diarrhea in both current and previous periods into the model. Diarrhea during the current period was associated with slower linear and ponderal growth. Faster (catch-up) growth in length was observed in children with no diarrhea in age groups immediately after an age group in which diarrhea was experienced [age group >6-12 mo: 0.03 mm/mo for each percentage diarrhea prevalence in the previous period (95% CI: 0.007, 0.06) relative to 11.3 mm/mo mean growth rate; age group >12-18 mo: 0.04 mm/mo (95% CI: 0.02, 0.06) relative to 8.9 mm/mo mean growth rate; age group >18-24 mo: 0.04 mm/mo (95% CI: 0.003, 0.09) relative to 7.9 mm/mo mean growth rate]. The associations were stronger in boys than in girls when separate models were run. Similar results were observed when weight was the outcome variable. When diarrheal episodes are followed by diarrhea-free periods in the first 2 y of life, catch-up growth is observed that may allow children to regain their original trajectories. The finding of a greater effect of diarrhea on linear growth in boys than in girls was unexpected and requires additional study. Diarrhea burdens are high throughout the first 2 y of life in these study sites, therefore reducing the likelihood of catch-up growth. Extending diarrhea-free periods may increase the likelihood of catch-up growth and decrease the prevalence of stunting.

KW - Body Height

KW - Child Development

KW - Child, Preschool

KW - Cohort Studies

KW - Diarrhea/complications

KW - Female

KW - Growth Disorders/epidemiology

KW - Humans

KW - Infant

KW - Longitudinal Studies

KW - Male

KW - Prevalence

KW - Reference Values

KW - Weight Gain/physiology

U2 - 10.3945/jn.113.187161

DO - 10.3945/jn.113.187161

M3 - Journal article

VL - 144

SP - 965

EP - 971

JO - The Journal of Nutrition

JF - The Journal of Nutrition

SN - 0022-3166

IS - 6

ER -

ID: 56805496