Carriers of the TCF7L2 rs7903146 TT genotype have elevated levels of plasma glucose, serum proinsulin and plasma gastric inhibitory polypeptide (GIP) during a meal test

A P Gjesing; L L Kjems; Marie Aare Vestmar; Niels Grarup; A Linneberg; Carolyn F. Deacon; J J Holst; O Pedersen; T Hansen

doi:10.1007/s00125-010-1940-4

Carriers of the TCF7L2 rs7903146 TT genotype have elevated levels of plasma glucose, serum proinsulin and plasma gastric inhibitory polypeptide (GIP) during a meal test

A P Gjesing, L L Kjems, Marie Aare Vestmar, Niels Grarup, A Linneberg, Carolyn F. Deacon, J J Holst, O Pedersen, T Hansen

23 Citationer (Scopus)

Abstract

The transcription factor 7-like 2 (TCF7L2) rs7903146 T allele associates with type 2 diabetes in several populations, possibly mediated via decreased incretin secretion and/or action and altered beta and alpha cell function. We aimed to study circulating levels of glucose, proinsulin, insulin, C-peptide, glucagon, glucagon-like peptide-1 (GLP-1), glucagon-like peptide-2 (GLP-2) and gastric inhibitory polypeptide (GIP) among individuals carrying the high-risk rs7903146 TT genotype and low-risk CC genotype following a meal test.

Originalsprog	Engelsk
Tidsskrift	Diabetologia
Vol/bind	54
Udgave nummer	1
Sider (fra-til)	103-10
Antal sider	8
ISSN	0012-186X
DOI	https://doi.org/10.1007/s00125-010-1940-4
Status	Udgivet - 2011

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10.1007/s00125-010-1940-4

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Gjesing, A. P., Kjems, L. L., Vestmar, M. A., Grarup, N., Linneberg, A., Deacon, C. F., Holst, J. J., Pedersen, O., & Hansen, T. (2011). Carriers of the TCF7L2 rs7903146 TT genotype have elevated levels of plasma glucose, serum proinsulin and plasma gastric inhibitory polypeptide (GIP) during a meal test. Diabetologia, 54(1), 103-10. https://doi.org/10.1007/s00125-010-1940-4

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abstract = "The transcription factor 7-like 2 (TCF7L2) rs7903146 T allele associates with type 2 diabetes in several populations, possibly mediated via decreased incretin secretion and/or action and altered beta and alpha cell function. We aimed to study circulating levels of glucose, proinsulin, insulin, C-peptide, glucagon, glucagon-like peptide-1 (GLP-1), glucagon-like peptide-2 (GLP-2) and gastric inhibitory polypeptide (GIP) among individuals carrying the high-risk rs7903146 TT genotype and low-risk CC genotype following a meal test.",

keywords = "Alleles, Blood Glucose, Gastric Inhibitory Polypeptide, Genetic Predisposition to Disease, Genotype, Humans, Male, Middle Aged, Proinsulin, Transcription Factor 7-Like 2 Protein",

author = "Gjesing, {A P} and Kjems, {L L} and Vestmar, {Marie Aare} and Niels Grarup and A Linneberg and Deacon, {Carolyn F.} and Holst, {J J} and O Pedersen and T Hansen",

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doi = "10.1007/s00125-010-1940-4",

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T1 - Carriers of the TCF7L2 rs7903146 TT genotype have elevated levels of plasma glucose, serum proinsulin and plasma gastric inhibitory polypeptide (GIP) during a meal test

AU - Gjesing, A P

AU - Kjems, L L

AU - Vestmar, Marie Aare

AU - Grarup, Niels

AU - Linneberg, A

AU - Deacon, Carolyn F.

AU - Holst, J J

AU - Pedersen, O

AU - Hansen, T

PY - 2011

Y1 - 2011

N2 - The transcription factor 7-like 2 (TCF7L2) rs7903146 T allele associates with type 2 diabetes in several populations, possibly mediated via decreased incretin secretion and/or action and altered beta and alpha cell function. We aimed to study circulating levels of glucose, proinsulin, insulin, C-peptide, glucagon, glucagon-like peptide-1 (GLP-1), glucagon-like peptide-2 (GLP-2) and gastric inhibitory polypeptide (GIP) among individuals carrying the high-risk rs7903146 TT genotype and low-risk CC genotype following a meal test.

AB - The transcription factor 7-like 2 (TCF7L2) rs7903146 T allele associates with type 2 diabetes in several populations, possibly mediated via decreased incretin secretion and/or action and altered beta and alpha cell function. We aimed to study circulating levels of glucose, proinsulin, insulin, C-peptide, glucagon, glucagon-like peptide-1 (GLP-1), glucagon-like peptide-2 (GLP-2) and gastric inhibitory polypeptide (GIP) among individuals carrying the high-risk rs7903146 TT genotype and low-risk CC genotype following a meal test.

KW - Alleles

KW - Blood Glucose

KW - Gastric Inhibitory Polypeptide

KW - Genetic Predisposition to Disease

KW - Genotype

KW - Humans

KW - Male

KW - Middle Aged

KW - Proinsulin

KW - Transcription Factor 7-Like 2 Protein

U2 - 10.1007/s00125-010-1940-4

DO - 10.1007/s00125-010-1940-4

M3 - Journal article

C2 - 20957343

SN - 0012-186X

VL - 54

SP - 103

EP - 110

JO - Diabetologia

JF - Diabetologia

IS - 1

ER -

Carriers of the TCF7L2 rs7903146 TT genotype have elevated levels of plasma glucose, serum proinsulin and plasma gastric inhibitory polypeptide (GIP) during a meal test

Abstract

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