Cardiovascular, metabolic, and hormonal responses to noradrenaline in diabetic patients with autonomic neuropathy

Anders Dejgaard, P Andersen, A Hvidberg, J Hilsted

12 Citationer (Scopus)

Abstract

Denervation hypersensitivity is a well-known phenomenon in patients with autonomic failure. In diabetic autonomic neuropathy hypersensitivity to beta-adrenergic stimulation has been demonstrated. We infused noradrenaline, mainly an alpha-adrenoceptor agonist, in three escalating doses (0.5, 2.5, and 5 micrograms min-1) in three age and sex matched groups of eight subjects: healthy volunteers, diabetic patients with and without autonomic neuropathy. During steady state in each infusion period we measured heart rate, blood pressure, cardiac output, hepato-splanchnic blood flow, vascular resistance, glucose kinetics, metabolites (beta-hydroxybuturate, glycerol, and lactate), and glucoregulatory hormones (noradrenaline, adrenaline, growth hormone, pancreatic polypeptide, cortisol, and insulin). Systolic and mean blood pressure increased in all groups but diabetic patients with autonomic neuropathy showed a significantly higher increase (p
OriginalsprogEngelsk
TidsskriftDiabetic Medicine
Vol/bind13
Udgave nummer11
Sider (fra-til)983-9
Antal sider7
ISSN0742-3071
DOI
StatusUdgivet - nov. 1996

Fingeraftryk

Dyk ned i forskningsemnerne om 'Cardiovascular, metabolic, and hormonal responses to noradrenaline in diabetic patients with autonomic neuropathy'. Sammen danner de et unikt fingeraftryk.

Citationsformater