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Cardiac natriuretic peptides

Publikation: Bidrag til tidsskriftReviewForskningpeer review

DOI

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  • Jens P Goetze
  • Benoit G Bruneau
  • Hugo R Ramos
  • Tsuneo Ogawa
  • Mercedes Kuroski de Bold
  • Adolfo J de Bold
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Investigations into the mixed muscle-secretory phenotype of cardiomyocytes from the atrial appendages of the heart led to the discovery that these cells produce, in a regulated manner, two polypeptide hormones - the natriuretic peptides - referred to as atrial natriuretic factor or atrial natriuretic peptide (ANP) and brain or B-type natriuretic peptide (BNP), thereby demonstrating an endocrine function for the heart. Studies on the gene encoding ANP (NPPA) initiated the field of modern research into gene regulation in the cardiovascular system. Additionally, ANP and BNP were found to be the natural ligands for cell membrane-bound guanylyl cyclase receptors that mediate the effects of natriuretic peptides through the generation of intracellular cGMP, which interacts with specific enzymes and ion channels. Natriuretic peptides have many physiological actions and participate in numerous pathophysiological processes. Important clinical entities associated with natriuretic peptide research include heart failure, obesity and systemic hypertension. Plasma levels of natriuretic peptides have proven to be powerful diagnostic and prognostic biomarkers of heart disease. Development of pharmacological agents that are based on natriuretic peptides is an area of active research, with vast potential benefits for the treatment of cardiovascular disease.

OriginalsprogEngelsk
TidsskriftNature Reviews Cardiology
Vol/bind17
Udgave nummer11
Sider (fra-til)698-717
Antal sider20
ISSN1759-5002
DOI
StatusUdgivet - nov. 2020

ID: 61253495