Cardiac effects of low-dose growth hormone replacement therapy in growth hormone-deficient adults. An 18-month randomised, placebo-controlled, double-blind study

Simone B Sneppen; Frank Steensgaard-Hansen; Ulla Feldt-Rasmussen

doi:10.1159/000063212

Cardiac effects of low-dose growth hormone replacement therapy in growth hormone-deficient adults. An 18-month randomised, placebo-controlled, double-blind study

Simone B Sneppen, Frank Steensgaard-Hansen, Ulla Feldt-Rasmussen

19 Citationer (Scopus)

Abstract

OBJECTIVE: To characterise the effect of long-term low-dose growth hormone (GH) treatment on cardiac anatomy and function.

METHODS: 20 patients with multiple pituitary hormone deficiencies, including severe acquired GH deficiency (GHD), were randomly assigned to GH or placebo (P) for 18 months. Echocardiographic measurements were performed at baseline and after 6, 12 and 18 months.

RESULTS: At baseline, 8 of 20 patients had diastolic dysfunction (6 severe and 2 borderline), while only 1 had systolic dysfunction. None of the investigated parameters of diastolic or systolic function changed during treatment.

CONCLUSION: In adult onset GHD, diastolic dysfunction was present in 40% of the patients. None of the investigated values were different after 18 months of GH compared to placebo.

Originalsprog	Engelsk
Tidsskrift	Hormone Research
Vol/bind	58
Udgave nummer	1
Sider (fra-til)	21-9
Antal sider	9
ISSN	0301-0163
DOI	https://doi.org/10.1159/000063212
Status	Udgivet - 2002

Adgang til dokumentet

10.1159/000063212

Citationsformater

Cardiac effects of low-dose growth hormone replacement therapy in growth hormone-deficient adults. An 18-month randomised, placebo-controlled, double-blind study. / Sneppen, Simone B; Steensgaard-Hansen, Frank; Feldt-Rasmussen, Ulla.
I: Hormone Research, Bind 58, Nr. 1, 2002, s. 21-9.

Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › peer review

@article{ca7d76134af1493da4749c5a57a450da,

title = "Cardiac effects of low-dose growth hormone replacement therapy in growth hormone-deficient adults. An 18-month randomised, placebo-controlled, double-blind study",

abstract = "OBJECTIVE: To characterise the effect of long-term low-dose growth hormone (GH) treatment on cardiac anatomy and function.METHODS: 20 patients with multiple pituitary hormone deficiencies, including severe acquired GH deficiency (GHD), were randomly assigned to GH or placebo (P) for 18 months. Echocardiographic measurements were performed at baseline and after 6, 12 and 18 months.RESULTS: At baseline, 8 of 20 patients had diastolic dysfunction (6 severe and 2 borderline), while only 1 had systolic dysfunction. None of the investigated parameters of diastolic or systolic function changed during treatment.CONCLUSION: In adult onset GHD, diastolic dysfunction was present in 40% of the patients. None of the investigated values were different after 18 months of GH compared to placebo.",

keywords = "Adenoma/drug therapy, Adult, Craniopharyngioma/drug therapy, Cushing Syndrome/drug therapy, Double-Blind Method, Female, Heart/anatomy & histology, Human Growth Hormone/deficiency, Humans, Male, Middle Aged, Myocardial Contraction/drug effects, Pituitary Neoplasms/drug therapy, Prolactinoma/drug therapy, Treatment Outcome, Ventricular Dysfunction, Left/mortality",

author = "Sneppen, {Simone B} and Frank Steensgaard-Hansen and Ulla Feldt-Rasmussen",

year = "2002",

doi = "10.1159/000063212",

language = "English",

volume = "58",

pages = "21--9",

journal = "Hormone Research",

issn = "0301-0163",

publisher = "S. Karger AG",

number = "1",

}

TY - JOUR

T1 - Cardiac effects of low-dose growth hormone replacement therapy in growth hormone-deficient adults. An 18-month randomised, placebo-controlled, double-blind study

AU - Sneppen, Simone B

AU - Steensgaard-Hansen, Frank

AU - Feldt-Rasmussen, Ulla

PY - 2002

Y1 - 2002

N2 - OBJECTIVE: To characterise the effect of long-term low-dose growth hormone (GH) treatment on cardiac anatomy and function.METHODS: 20 patients with multiple pituitary hormone deficiencies, including severe acquired GH deficiency (GHD), were randomly assigned to GH or placebo (P) for 18 months. Echocardiographic measurements were performed at baseline and after 6, 12 and 18 months.RESULTS: At baseline, 8 of 20 patients had diastolic dysfunction (6 severe and 2 borderline), while only 1 had systolic dysfunction. None of the investigated parameters of diastolic or systolic function changed during treatment.CONCLUSION: In adult onset GHD, diastolic dysfunction was present in 40% of the patients. None of the investigated values were different after 18 months of GH compared to placebo.

AB - OBJECTIVE: To characterise the effect of long-term low-dose growth hormone (GH) treatment on cardiac anatomy and function.METHODS: 20 patients with multiple pituitary hormone deficiencies, including severe acquired GH deficiency (GHD), were randomly assigned to GH or placebo (P) for 18 months. Echocardiographic measurements were performed at baseline and after 6, 12 and 18 months.RESULTS: At baseline, 8 of 20 patients had diastolic dysfunction (6 severe and 2 borderline), while only 1 had systolic dysfunction. None of the investigated parameters of diastolic or systolic function changed during treatment.CONCLUSION: In adult onset GHD, diastolic dysfunction was present in 40% of the patients. None of the investigated values were different after 18 months of GH compared to placebo.

KW - Adenoma/drug therapy

KW - Adult

KW - Craniopharyngioma/drug therapy

KW - Cushing Syndrome/drug therapy

KW - Double-Blind Method

KW - Female

KW - Heart/anatomy & histology

KW - Human Growth Hormone/deficiency

KW - Humans

KW - Male

KW - Middle Aged

KW - Myocardial Contraction/drug effects

KW - Pituitary Neoplasms/drug therapy

KW - Prolactinoma/drug therapy

KW - Treatment Outcome

KW - Ventricular Dysfunction, Left/mortality

U2 - 10.1159/000063212

DO - 10.1159/000063212

M3 - Journal article

C2 - 12169777

SN - 0301-0163

VL - 58

SP - 21

EP - 29

JO - Hormone Research

JF - Hormone Research

IS - 1

ER -

Cardiac effects of low-dose growth hormone replacement therapy in growth hormone-deficient adults. An 18-month randomised, placebo-controlled, double-blind study

Abstract

Adgang til dokumentet

Fingeraftryk

Citationsformater