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Region Hovedstaden - en del af Københavns Universitetshospital
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Cardiac biomarkers retain prognostic significance in patients with heart failure and chronic obstructive pulmonary disease

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

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  • Giuseppe Vergaro
  • Alberto Aimo
  • James L Januzzi
  • A Mark Richards
  • Carolyn S P Lam
  • Roberto Latini
  • Lidia Staszewsky
  • Inder S Anand
  • Thor Ueland
  • Hans-Peter Brunner-La Rocca
  • Antoni Bayes-Genis
  • Josep Lupón
  • Rudolf A de Boer
  • Akiomi Yoshihisa
  • Yasuchika Takeishi
  • Ida Gustafsson
  • Kai M Eggers
  • Kurt Huber
  • Greg D Gamble
  • Kui Toh Gerard Leong
  • Poh Shuan Daniel Yeo
  • Hean Yee Ong
  • Fazlur Jaufeerally
  • Tze P Ng
  • Richard Troughton
  • Robert N Doughty
  • Michele Emdin
  • Claudio Passino
Vis graf over relationer

AIMS: Chronic obstructive pulmonary disease (COPD) is a frequent comorbidity in patients with heart failure (HF). We assessed the influence of COPD on circulating levels and prognostic value of three HF biomarkers: N-terminal pro-B-type natriuretic peptide (NT-proBNP), high-sensitivity troponin T (hs-TnT), and soluble suppression of tumorigenesis-2 (sST2).

METHODS: Individual data from patients with chronic HF, known COPD status, NT-proBNP and hs-TnT values (n = 8088) were analysed. A subgroup (n = 3414) had also sST2 values.

RESULTS: Patients had a median age of 66 years (interquartile interval 57-74), 77% were men and 82% had HF with reduced ejection fraction. NT-proBNP, hs-TnT and sST2 were 1207 ng/l (487-2725), 17 ng/l (9-31) and 30 ng/ml (22-44), respectively. Patients with COPD (n = 1249, 15%) had higher NT-proBNP (P = 0.042) and hs-TnT (P < 0.001), but not sST2 (P = 0.165). Over a median 2.0-year follow-up (1.5-2.5), 1717 patients (21%) died, and 1298 (16%) died from cardiovascular causes; 2255 patients (28%) were hospitalized for HF over 1.8 years (0.9-2.1). NT-proBNP, hs-TnT and sST2 predicted the three end points regardless of COPD status. The best cut-offs from receiver-operating characteristics analysis were higher in patients with COPD than in those without. Patients with all three biomarkers higher than or equal to end-point- and COPD-status-specific cut-offs were also those with the worst prognosis.

CONCLUSIONS: Among patients with HF, those with COPD have higher NT-proBNP and hs-TnT, but not sST2. All these biomarkers yield prognostic significance regardless of the COPD status.

OriginalsprogEngelsk
TidsskriftJournal of Cardiovascular Medicine
Vol/bind23
Udgave nummer1
Sider (fra-til)28-36
Antal sider9
ISSN1558-2027
DOI
StatusUdgivet - 1 jan. 2022

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