Carcinoma in situ testis displays permissive chromatin modifications similar to immature foetal germ cells

K Almstrup; J E Nielsen; O Mlynarska; M T Jansen; A Jørgensen; N E Skakkebæk; E Rajpert-De Meyts

doi:10.1038/sj.bjc.6605880

Carcinoma in situ testis displays permissive chromatin modifications similar to immature foetal germ cells

Afdeling for Vækst og Reproduktion JMC

78 Citationer (Scopus)

Abstract

The majority of testicular germ cell cancers develop through a pre-invasive carcinoma in situ (CIS) stage. The CIS cell is a neoplastic counterpart of foetal germ cells. During their development, foetal germ cells undergo extensive and essential epigenetic modifications, but little is known about epigenetic patterns in CIS cells.

Originalsprog	Engelsk
Tidsskrift	British Journal of Cancer
Vol/bind	103
Udgave nummer	8
Sider (fra-til)	1269-76
Antal sider	8
ISSN	0007-0920
DOI	https://doi.org/10.1038/sj.bjc.6605880
Status	Udgivet - 12 okt. 2010

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10.1038/sj.bjc.6605880

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title = "Carcinoma in situ testis displays permissive chromatin modifications similar to immature foetal germ cells",

abstract = "The majority of testicular germ cell cancers develop through a pre-invasive carcinoma in situ (CIS) stage. The CIS cell is a neoplastic counterpart of foetal germ cells. During their development, foetal germ cells undergo extensive and essential epigenetic modifications, but little is known about epigenetic patterns in CIS cells.",

author = "K Almstrup and Nielsen, \{J E\} and O Mlynarska and Jansen, \{M T\} and A J{\o}rgensen and Skakkeb{\ae}k, \{N E\} and \{Rajpert-De Meyts\}, E",

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T1 - Carcinoma in situ testis displays permissive chromatin modifications similar to immature foetal germ cells

AU - Almstrup, K

AU - Nielsen, J E

AU - Mlynarska, O

AU - Jansen, M T

AU - Jørgensen, A

AU - Skakkebæk, N E

AU - Rajpert-De Meyts, E

PY - 2010/10/12

Y1 - 2010/10/12

N2 - The majority of testicular germ cell cancers develop through a pre-invasive carcinoma in situ (CIS) stage. The CIS cell is a neoplastic counterpart of foetal germ cells. During their development, foetal germ cells undergo extensive and essential epigenetic modifications, but little is known about epigenetic patterns in CIS cells.

AB - The majority of testicular germ cell cancers develop through a pre-invasive carcinoma in situ (CIS) stage. The CIS cell is a neoplastic counterpart of foetal germ cells. During their development, foetal germ cells undergo extensive and essential epigenetic modifications, but little is known about epigenetic patterns in CIS cells.

U2 - 10.1038/sj.bjc.6605880

DO - 10.1038/sj.bjc.6605880

M3 - Journal article

C2 - 20823885

SN - 0007-0920

VL - 103

SP - 1269

EP - 1276

JO - British Journal of Cancer

JF - British Journal of Cancer

IS - 8

ER -

Carcinoma in situ testis displays permissive chromatin modifications similar to immature foetal germ cells

Abstract

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