TY - JOUR
T1 - Carcinoma in situ, gonadoblastoma, and early invasive neoplasia in a nine-year-old girl with 46,XY gonadal dysgenesis
AU - Müller, J
AU - Visfeldt, J
AU - Philip, J
AU - Skakkebaek, N E
PY - 1992/2
Y1 - 1992/2
N2 - Carcinoma in situ (CIS), gonadoblastoma, and early invasive neoplasia were detected in the dysgenetic gonad of a nine-year-old girl with 46,XY gonadal dysgenesis. A close relationship between the three neoplastic components was supported by morphological and immunohistochemical studies. Our findings support the hypothesis that all germ cell tumours, including gonadoblastomas, originate from CIS germ cells formed during early embryonic life.
AB - Carcinoma in situ (CIS), gonadoblastoma, and early invasive neoplasia were detected in the dysgenetic gonad of a nine-year-old girl with 46,XY gonadal dysgenesis. A close relationship between the three neoplastic components was supported by morphological and immunohistochemical studies. Our findings support the hypothesis that all germ cell tumours, including gonadoblastomas, originate from CIS germ cells formed during early embryonic life.
KW - Carcinoma in Situ/genetics
KW - Child
KW - Dysgerminoma/genetics
KW - Female
KW - Gonadal Dysgenesis, 46,XY/complications
KW - Humans
KW - Neoplasm Invasiveness
KW - Ovarian Neoplasms/genetics
U2 - 10.1111/j.1699-0463.1992.tb00857.x
DO - 10.1111/j.1699-0463.1992.tb00857.x
M3 - Journal article
C2 - 1554492
SN - 0903-4641
VL - 100
SP - 170
EP - 174
JO - APMIS - Journal of Pathology, Microbiology and Immunology
JF - APMIS - Journal of Pathology, Microbiology and Immunology
IS - 2
ER -