Carboxylesterase 1 gene duplication and mRNA expression in adipose tissue are linked to obesity and metabolic function

Martin Friedrichsen, Pernille Hartveit Poulsen, Jørgen Wojtaszewski, Peter Riis Hansen, Allan Vaag, Henrik Berg Rasmussen

21 Citationer (Scopus)

Abstract

CONTEXT AND AIMS: Carboxylesterase 1 (CES1) appears to play an important role in the control of the metabolism of triglycerides and cholesterol in adipocytes and other cell types including hepatocytes. Therefore, it is relevant to gain insights into the genetic versus non-genetic mechanisms involved in the control of CES1 mRNA expression. Here, we investigated CES1 mRNA expression level in adipose tissue and its association with measures of adiposity and metabolic function in a population of elderly twins. Furthermore, the heritability of CES1 mRNA expression level in adipose tissue and the effect of CES1 gene duplication were assessed.
OriginalsprogEngelsk
TidsskriftP L o S One
Vol/bind8
Udgave nummer2
Sider (fra-til)e56861
ISSN1932-6203
DOI
StatusUdgivet - 2013

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