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Region Hovedstaden - en del af Københavns Universitetshospital
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Capillary dysfunction is associated with symptom severity and neurodegeneration in Alzheimer's disease

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  • Rune B Nielsen
  • Lærke Egefjord
  • Hugo Angleys
  • Kim Mouridsen
  • Michael Gejl
  • Arne Møller
  • Birgitte Brock
  • Hans Brændgaard
  • Hanne Gottrup
  • Jørgen Rungby
  • Simon Fristed Eskildsen
  • Leif Østergaard
Vis graf over relationer

INTRODUCTION: We examined whether cortical microvascular blood volume and hemodynamics in Alzheimer's disease (AD) are consistent with tissue hypoxia and whether they correlate with cognitive performance and the degree of cortical thinning.

METHODS: Thirty-two AD patients underwent cognitive testing, structural magnetic resonance imaging (MRI), and perfusion MRI at baseline and after 6 months. We measured cortical thickness, microvascular cerebral blood volume (CBV), cerebral blood flow (CBF), mean transit time (MTT), and capillary transit time heterogeneity (CTH) and estimated tissue oxygen tension (PtO2).

RESULTS: At baseline, poor cognitive performance and regional cortical thinning correlated with lower CBF and CBV, with higher MTT and CTH and with low PtO2 across the cortex. Cognitive decline over time was associated with increasing whole brain relative transit time heterogeneity (RTH = CTH/MTT).

DISCUSSION: Our results confirm the importance of microvascular pathology in AD. Deteriorating microvascular hemodynamics may cause hypoxia, which is known to precipitate amyloid retention.

OriginalsprogEngelsk
TidsskriftAlzheimer's & dementia : the journal of the Alzheimer's Association
Vol/bind13
Udgave nummer10
Sider (fra-til)1143–1153
ISSN1552-5260
DOI
StatusUdgivet - okt. 2017

ID: 51418747