Cancer of the external auditory canal and middle ear in Denmark from 1992 to 2001

Anders Rørbaek Madsen, Maria G Gundgaard, Camilla M Hoff, Christian Maare, Peter Holmboe, Marianne Knap, Lone L Thomsen, Christian Buchwald, Hanne S Hansen, Poul Bretlau, Cai Grau

64 Citationer (Scopus)

Abstract

BACKGROUND: In the context of the Danish Head and Neck Cancer Group, nationwide material from 1992-2001 was analyzed to study the extent and nature of the disease, evaluate treatment, compare staging systems, and examine prognosis and survival.

METHODS: Review of 68 consecutive cases: 47 squamous cell carcinoma, 10 basal cell carcinoma, and 11 other histologies. Moody (modified Pittsburgh) stages were T1 (26), T2 (9), T3 (8), T4 (23), Tx (2). Sixty-four patients were treated with curative intent: 24 primary radiotherapy, 18 primary surgery, and 22 combined. Surgery was limited to tumor excision and mastoidectomy and in 1 case temporal bone excision.

RESULTS: Twenty-seven of 28 recurrences involved primary site. Kaplan-Meier analysis showed 5-year locoregional control of 48%, disease-specific survival 57%, and overall survival 44%.

CONCLUSION: This nationwide study confirmed that local failure is the main problem, and future improvements should focus on more aggressive local treatment.

OriginalsprogEngelsk
TidsskriftHead and Neck
Vol/bind30
Udgave nummer10
Sider (fra-til)1332-8
Antal sider7
ISSN1043-3074
DOI
StatusUdgivet - okt. 2008
Udgivet eksterntJa

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