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Cancer of the corpus uteri

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@article{8a722a8337e34f99b545f12c118b8555,
title = "Cancer of the corpus uteri",
abstract = "Endometrial cancer is the most common gynecological malignancy in high-income countries. Although the overall prognosis is relatively good, high-grade endometrial cancers have a tendency to recur. Recurrence needs to be prevented since the prognosis for recurrent endometrial cancer is dismal. Treatment tailored to tumor biology is the optimal strategy to balance treatment efficacy against toxicity. Standard treatment consists of hysterectomy and bilateral salpingo-oophorectomy. Lymphadenectomy (with ongoing studies of sentinel node biopsy) enables identification of lymph node positive patients who need adjuvant treatment, including radiotherapy and chemotherapy. Adjuvant radiotherapy is used for Stage I-II patients with high-risk factors and Stage III lymph node negative patients. In advanced disease, a combination of surgery to no residual disease and chemotherapy results in the best outcome. Surgery for recurrent disease is only advocated in patients with a good performance status with a relatively long disease-free interval.",
keywords = "Aged, Endometrial Neoplasms/pathology, Female, Humans, Hysterectomy/methods, Lymph Node Excision/methods, Middle Aged, Neoplasm Recurrence, Local/pathology, Neoplasm Staging, Prognosis, Radiotherapy, Adjuvant, Salpingo-oophorectomy/methods",
author = "Fr{\'e}d{\'e}ric Amant and Mirza, {Mansoor Raza} and Martin Koskas and Creutzberg, {Carien L}",
note = "{\circledC} 2018 The Authors. International Journal of Gynecology & Obstetrics published by John Wiley & Sons Ltd on behalf of International Federation of Gynecology and Obstetrics.",
year = "2018",
month = "10",
doi = "10.1002/ijgo.12612",
language = "English",
volume = "143 Suppl 2",
pages = "37--50",
journal = "International Journal of Gynecology and Obstetrics",
issn = "0020-7292",
publisher = "Elsevier Ireland Ltd",

}

RIS

TY - JOUR

T1 - Cancer of the corpus uteri

AU - Amant, Frédéric

AU - Mirza, Mansoor Raza

AU - Koskas, Martin

AU - Creutzberg, Carien L

N1 - © 2018 The Authors. International Journal of Gynecology & Obstetrics published by John Wiley & Sons Ltd on behalf of International Federation of Gynecology and Obstetrics.

PY - 2018/10

Y1 - 2018/10

N2 - Endometrial cancer is the most common gynecological malignancy in high-income countries. Although the overall prognosis is relatively good, high-grade endometrial cancers have a tendency to recur. Recurrence needs to be prevented since the prognosis for recurrent endometrial cancer is dismal. Treatment tailored to tumor biology is the optimal strategy to balance treatment efficacy against toxicity. Standard treatment consists of hysterectomy and bilateral salpingo-oophorectomy. Lymphadenectomy (with ongoing studies of sentinel node biopsy) enables identification of lymph node positive patients who need adjuvant treatment, including radiotherapy and chemotherapy. Adjuvant radiotherapy is used for Stage I-II patients with high-risk factors and Stage III lymph node negative patients. In advanced disease, a combination of surgery to no residual disease and chemotherapy results in the best outcome. Surgery for recurrent disease is only advocated in patients with a good performance status with a relatively long disease-free interval.

AB - Endometrial cancer is the most common gynecological malignancy in high-income countries. Although the overall prognosis is relatively good, high-grade endometrial cancers have a tendency to recur. Recurrence needs to be prevented since the prognosis for recurrent endometrial cancer is dismal. Treatment tailored to tumor biology is the optimal strategy to balance treatment efficacy against toxicity. Standard treatment consists of hysterectomy and bilateral salpingo-oophorectomy. Lymphadenectomy (with ongoing studies of sentinel node biopsy) enables identification of lymph node positive patients who need adjuvant treatment, including radiotherapy and chemotherapy. Adjuvant radiotherapy is used for Stage I-II patients with high-risk factors and Stage III lymph node negative patients. In advanced disease, a combination of surgery to no residual disease and chemotherapy results in the best outcome. Surgery for recurrent disease is only advocated in patients with a good performance status with a relatively long disease-free interval.

KW - Aged

KW - Endometrial Neoplasms/pathology

KW - Female

KW - Humans

KW - Hysterectomy/methods

KW - Lymph Node Excision/methods

KW - Middle Aged

KW - Neoplasm Recurrence, Local/pathology

KW - Neoplasm Staging

KW - Prognosis

KW - Radiotherapy, Adjuvant

KW - Salpingo-oophorectomy/methods

U2 - 10.1002/ijgo.12612

DO - 10.1002/ijgo.12612

M3 - Journal article

VL - 143 Suppl 2

SP - 37

EP - 50

JO - International Journal of Gynecology and Obstetrics

JF - International Journal of Gynecology and Obstetrics

SN - 0020-7292

ER -

ID: 55906993