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Cancer in pregnancy increases the risk of venous thromboembolism: A nationwide cohort study

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@article{9519f7f1c197491d9f1498089ced6445,
title = "Cancer in pregnancy increases the risk of venous thromboembolism: A nationwide cohort study",
abstract = "OBJECTIVE: To investigate if cancer in pregnancy causes a higher risk of venous thromboembolism (VTE) during pregnancy and postpartum compared with pregnant women without cancer.DESIGN: A historical prospective cohort study using data from nationwide registries.SETTING AND POPULATION: We assessed all pregnancies in Denmark between 1 January 1977 and 31 December 2017.METHODS: We linked information concerning cancer diagnosis, pregnancy and VTE diagnosis and potential confounders. Event rates of VTE for women with pre-pregnancy cancer, cancer in pregnancy and without cancer were calculated per 10 000 pregnancies and compared using logistic regression analysis.MAIN OUTCOME MEASURES: Occurrence of VTE during pregnancy or the postpartum period.RESULTS: A total of 3 581 214 pregnancies were included in the study and we found 1330 women with cancer in pregnancy. In pregnant women with cancer, the event rate of VTE was 75.2 per 10 000 pregnancies compared with 10.7 per 10 000 pregnancies in the no cancer group. The findings correspond to an increased adjusted odds ratio of 6.50 (95% CI3.5-12.1) in the cancer in pregnancy group in comparison with the no cancer group.CONCLUSIONS: Women with cancer in pregnancy have a markedly higher risk of pregnancy-associated VTE compared with women without cancer. In pregnancy-related VTE risk assessment, the presence of cancer alone may be sufficient to indicate thromboprophylaxis.TWEETABLE ABSTRACT: Cancer in pregnancy increases the risk of VTE during pregnancy and the postpartum period.",
keywords = "Cancer in pregnancy, postpartum period, venous thromboembolism",
author = "Greiber, {Iben Katinka} and Mikkelsen, {Anders Pretzmann} and Karlsen, {Mona Aarenstrup} and Lone Storgaard and Jakob Viuff and Lene Mellemkjaer and Hjortsh{\o}j, {Cristel S{\o}rensen} and {\O}jvind Lidegaard",
note = "{\textcopyright} 2021 John Wiley & Sons Ltd.",
year = "2021",
month = jun,
doi = "10.1111/1471-0528.16627",
language = "English",
volume = "128",
pages = "1151--1159",
journal = "BJOG: An International Journal of Obstetrics and Gynaecology",
issn = "1470-0328",
publisher = "Wiley-Blackwell Publishing Ltd",
number = "7",

}

RIS

TY - JOUR

T1 - Cancer in pregnancy increases the risk of venous thromboembolism

T2 - A nationwide cohort study

AU - Greiber, Iben Katinka

AU - Mikkelsen, Anders Pretzmann

AU - Karlsen, Mona Aarenstrup

AU - Storgaard, Lone

AU - Viuff, Jakob

AU - Mellemkjaer, Lene

AU - Hjortshøj, Cristel Sørensen

AU - Lidegaard, Øjvind

N1 - © 2021 John Wiley & Sons Ltd.

PY - 2021/6

Y1 - 2021/6

N2 - OBJECTIVE: To investigate if cancer in pregnancy causes a higher risk of venous thromboembolism (VTE) during pregnancy and postpartum compared with pregnant women without cancer.DESIGN: A historical prospective cohort study using data from nationwide registries.SETTING AND POPULATION: We assessed all pregnancies in Denmark between 1 January 1977 and 31 December 2017.METHODS: We linked information concerning cancer diagnosis, pregnancy and VTE diagnosis and potential confounders. Event rates of VTE for women with pre-pregnancy cancer, cancer in pregnancy and without cancer were calculated per 10 000 pregnancies and compared using logistic regression analysis.MAIN OUTCOME MEASURES: Occurrence of VTE during pregnancy or the postpartum period.RESULTS: A total of 3 581 214 pregnancies were included in the study and we found 1330 women with cancer in pregnancy. In pregnant women with cancer, the event rate of VTE was 75.2 per 10 000 pregnancies compared with 10.7 per 10 000 pregnancies in the no cancer group. The findings correspond to an increased adjusted odds ratio of 6.50 (95% CI3.5-12.1) in the cancer in pregnancy group in comparison with the no cancer group.CONCLUSIONS: Women with cancer in pregnancy have a markedly higher risk of pregnancy-associated VTE compared with women without cancer. In pregnancy-related VTE risk assessment, the presence of cancer alone may be sufficient to indicate thromboprophylaxis.TWEETABLE ABSTRACT: Cancer in pregnancy increases the risk of VTE during pregnancy and the postpartum period.

AB - OBJECTIVE: To investigate if cancer in pregnancy causes a higher risk of venous thromboembolism (VTE) during pregnancy and postpartum compared with pregnant women without cancer.DESIGN: A historical prospective cohort study using data from nationwide registries.SETTING AND POPULATION: We assessed all pregnancies in Denmark between 1 January 1977 and 31 December 2017.METHODS: We linked information concerning cancer diagnosis, pregnancy and VTE diagnosis and potential confounders. Event rates of VTE for women with pre-pregnancy cancer, cancer in pregnancy and without cancer were calculated per 10 000 pregnancies and compared using logistic regression analysis.MAIN OUTCOME MEASURES: Occurrence of VTE during pregnancy or the postpartum period.RESULTS: A total of 3 581 214 pregnancies were included in the study and we found 1330 women with cancer in pregnancy. In pregnant women with cancer, the event rate of VTE was 75.2 per 10 000 pregnancies compared with 10.7 per 10 000 pregnancies in the no cancer group. The findings correspond to an increased adjusted odds ratio of 6.50 (95% CI3.5-12.1) in the cancer in pregnancy group in comparison with the no cancer group.CONCLUSIONS: Women with cancer in pregnancy have a markedly higher risk of pregnancy-associated VTE compared with women without cancer. In pregnancy-related VTE risk assessment, the presence of cancer alone may be sufficient to indicate thromboprophylaxis.TWEETABLE ABSTRACT: Cancer in pregnancy increases the risk of VTE during pregnancy and the postpartum period.

KW - Cancer in pregnancy

KW - postpartum period

KW - venous thromboembolism

UR - http://www.scopus.com/inward/record.url?scp=85099259927&partnerID=8YFLogxK

U2 - 10.1111/1471-0528.16627

DO - 10.1111/1471-0528.16627

M3 - Journal article

C2 - 33314607

VL - 128

SP - 1151

EP - 1159

JO - BJOG: An International Journal of Obstetrics and Gynaecology

JF - BJOG: An International Journal of Obstetrics and Gynaecology

SN - 1470-0328

IS - 7

ER -

ID: 61649378