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Cancer After Liver Transplantation in Children and Young Adults: A Population-Based Study From 4 Nordic Countries

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Harvard

Åberg, F, Isoniemi, H, Pukkala, E, Jalanko, H, Rasmussen, A, Storm, HH, Schultz, N, Bennet, W, Ekvall, N, Ericzon, B-G, Malenicka, S, Tretli, S, Line, P-D, Boberg, KM, Østensen, A, Karlsen, TH & Nordin, A 2018, 'Cancer After Liver Transplantation in Children and Young Adults: A Population-Based Study From 4 Nordic Countries', Liver Transplantation, bind 24, nr. 9, s. 1252-1259. https://doi.org/10.1002/lt.25305

APA

Åberg, F., Isoniemi, H., Pukkala, E., Jalanko, H., Rasmussen, A., Storm, H. H., Schultz, N., Bennet, W., Ekvall, N., Ericzon, B-G., Malenicka, S., Tretli, S., Line, P-D., Boberg, K. M., Østensen, A., Karlsen, T. H., & Nordin, A. (2018). Cancer After Liver Transplantation in Children and Young Adults: A Population-Based Study From 4 Nordic Countries. Liver Transplantation, 24(9), 1252-1259. https://doi.org/10.1002/lt.25305

CBE

Åberg F, Isoniemi H, Pukkala E, Jalanko H, Rasmussen A, Storm HH, Schultz N, Bennet W, Ekvall N, Ericzon B-G, Malenicka S, Tretli S, Line P-D, Boberg KM, Østensen A, Karlsen TH, Nordin A. 2018. Cancer After Liver Transplantation in Children and Young Adults: A Population-Based Study From 4 Nordic Countries. Liver Transplantation. 24(9):1252-1259. https://doi.org/10.1002/lt.25305

MLA

Vancouver

Author

Åberg, Fredrik ; Isoniemi, Helena ; Pukkala, Eero ; Jalanko, Hannu ; Rasmussen, Allan ; Storm, Hans H ; Schultz, Nicolai ; Bennet, William ; Ekvall, Nils ; Ericzon, Bo-Göran ; Malenicka, Silvia ; Tretli, Steinar ; Line, Pål-Dag ; Boberg, Kirsten Muri ; Østensen, Anniken ; Karlsen, Tom Hemming ; Nordin, Arno. / Cancer After Liver Transplantation in Children and Young Adults : A Population-Based Study From 4 Nordic Countries. I: Liver Transplantation. 2018 ; Bind 24, Nr. 9. s. 1252-1259.

Bibtex

@article{84a31007bcce4ede9257273693c976d2,
title = "Cancer After Liver Transplantation in Children and Young Adults: A Population-Based Study From 4 Nordic Countries",
abstract = "Cancer after liver transplantation (LT) constitutes a threat also for young recipients, but cancer risk factors are usually absent in children and large studies on the cancer risk profile in young LT recipients are scarce. Data of patients younger than 30 years who underwent LT during the period 1982-2013 in the Nordic countries were linked with respective national cancer registries to calculate standardized incidence ratios (SIRs). A total of 37 cancer cases were observed in 923 patients with 7846 person-years of follow-up. The SIR for all cancer types, compared with the matched general population, was 9.8 (12.4 for males and 7.8 for females). Cumulative incidence of cancer adjusted for the competing risk of death was 2% at 10 years, 6% at 20 years, and 22% at 25 years after LT. Non-Hodgkin lymphoma was the most common cancer type (n = 14) followed by colorectal (n = 4) and hepatocellular cancer (n = 4). Age was a significant risk factor for cancer, and the absolute risk of most cancers (except for lymphoma) increased considerably in young adults older than 20 years. The cancer risk pattern is different in pediatric and young LT patients compared with adult recipients. The striking increase in cancer incidence in young adulthood after the second decade of life deserves further consideration in transition programs.",
author = "Fredrik {\AA}berg and Helena Isoniemi and Eero Pukkala and Hannu Jalanko and Allan Rasmussen and Storm, {Hans H} and Nicolai Schultz and William Bennet and Nils Ekvall and Bo-G{\"o}ran Ericzon and Silvia Malenicka and Steinar Tretli and P{\aa}l-Dag Line and Boberg, {Kirsten Muri} and Anniken {\O}stensen and Karlsen, {Tom Hemming} and Arno Nordin",
note = "{\textcopyright} 2018 by the American Association for the Study of Liver Diseases.",
year = "2018",
month = sep,
doi = "10.1002/lt.25305",
language = "English",
volume = "24",
pages = "1252--1259",
journal = "Liver Transplantation",
issn = "1527-6465",
publisher = "JohnWiley & Sons, Inc",
number = "9",

}

RIS

TY - JOUR

T1 - Cancer After Liver Transplantation in Children and Young Adults

T2 - A Population-Based Study From 4 Nordic Countries

AU - Åberg, Fredrik

AU - Isoniemi, Helena

AU - Pukkala, Eero

AU - Jalanko, Hannu

AU - Rasmussen, Allan

AU - Storm, Hans H

AU - Schultz, Nicolai

AU - Bennet, William

AU - Ekvall, Nils

AU - Ericzon, Bo-Göran

AU - Malenicka, Silvia

AU - Tretli, Steinar

AU - Line, Pål-Dag

AU - Boberg, Kirsten Muri

AU - Østensen, Anniken

AU - Karlsen, Tom Hemming

AU - Nordin, Arno

N1 - © 2018 by the American Association for the Study of Liver Diseases.

PY - 2018/9

Y1 - 2018/9

N2 - Cancer after liver transplantation (LT) constitutes a threat also for young recipients, but cancer risk factors are usually absent in children and large studies on the cancer risk profile in young LT recipients are scarce. Data of patients younger than 30 years who underwent LT during the period 1982-2013 in the Nordic countries were linked with respective national cancer registries to calculate standardized incidence ratios (SIRs). A total of 37 cancer cases were observed in 923 patients with 7846 person-years of follow-up. The SIR for all cancer types, compared with the matched general population, was 9.8 (12.4 for males and 7.8 for females). Cumulative incidence of cancer adjusted for the competing risk of death was 2% at 10 years, 6% at 20 years, and 22% at 25 years after LT. Non-Hodgkin lymphoma was the most common cancer type (n = 14) followed by colorectal (n = 4) and hepatocellular cancer (n = 4). Age was a significant risk factor for cancer, and the absolute risk of most cancers (except for lymphoma) increased considerably in young adults older than 20 years. The cancer risk pattern is different in pediatric and young LT patients compared with adult recipients. The striking increase in cancer incidence in young adulthood after the second decade of life deserves further consideration in transition programs.

AB - Cancer after liver transplantation (LT) constitutes a threat also for young recipients, but cancer risk factors are usually absent in children and large studies on the cancer risk profile in young LT recipients are scarce. Data of patients younger than 30 years who underwent LT during the period 1982-2013 in the Nordic countries were linked with respective national cancer registries to calculate standardized incidence ratios (SIRs). A total of 37 cancer cases were observed in 923 patients with 7846 person-years of follow-up. The SIR for all cancer types, compared with the matched general population, was 9.8 (12.4 for males and 7.8 for females). Cumulative incidence of cancer adjusted for the competing risk of death was 2% at 10 years, 6% at 20 years, and 22% at 25 years after LT. Non-Hodgkin lymphoma was the most common cancer type (n = 14) followed by colorectal (n = 4) and hepatocellular cancer (n = 4). Age was a significant risk factor for cancer, and the absolute risk of most cancers (except for lymphoma) increased considerably in young adults older than 20 years. The cancer risk pattern is different in pediatric and young LT patients compared with adult recipients. The striking increase in cancer incidence in young adulthood after the second decade of life deserves further consideration in transition programs.

U2 - 10.1002/lt.25305

DO - 10.1002/lt.25305

M3 - Journal article

C2 - 30120902

VL - 24

SP - 1252

EP - 1259

JO - Liver Transplantation

JF - Liver Transplantation

SN - 1527-6465

IS - 9

ER -

ID: 56537785