Forskning
Udskriv Udskriv
Switch language
Region Hovedstaden - en del af Københavns Universitetshospital
Udgivet

Can we identify allergic rhinitis from administrative data: A validation study

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

DOI

  1. Tramadol use in Norway: A register-based population study

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  2. Multi-centre, multi-database studies with common protocols: Lessons learnt from the IMI PROTECT project

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  3. Hypnotics and mortality--partial confounding by disease, substance abuse and socioeconomic factors?

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  1. Genome-Wide Association Analysis of Pancreatic Beta Cell Glucose Sensitivity

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  2. FUT2-ABO epistasis increases the risk of early childhood asthma and Streptococcus pneumoniae respiratory illnesses

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  3. Genetic Studies of Leptin Concentrations Implicate Leptin in the Regulation of Early Adiposity

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

Vis graf over relationer

BACKGROUND: Important insights on, for example, prevalence, disease progression, and treatment of allergic rhinitis can be obtained from large-scale database studies if researchers are able to identify allergic individuals. We aimed to assess the validity of 13 different algorithms based on Danish nationwide prescription and/or hospital data to identify adults with allergic rhinitis.

METHODS: Our primary gold standard of allergic rhinitis was a positive serum specific IgE (≥0.35) and self-reported nasal symptoms retrieved from two general health examination studies conducted in Danish adults (18-69 years) during 2006 to 2008 (n = 3416) and 2012 to 2015 (n = 7237). The secondary gold standard of allergic rhinitis was self-reported physician diagnosis. We calculated sensitivity, specificity, positive predictive value (PPV), negative predictive value, and corresponding 95% confidence intervals (95% CI) for each register-based algorithm in the two time periods.

RESULTS: Sensitivity (≤0.40) was low for all algorithms irrespective of definition of allergic rhinitis (gold standard) or time period. The highest PPVs were obtained for algorithms requiring both antihistamines and intranasal corticosteroids; yielding a PPV of 0.69 (0.62-0.75) and a corresponding sensitivity of 0.10 (0.09-0.12) for the primary gold standard of allergic rhinitis in 2012 to 2015.

CONCLUSION: Algorithms based on both antihistamines and intranasal corticosteroids yielded the highest PPVs. However, the PPVs were still moderate and came at the expense of low sensitivity when applying the strict primary gold standard (sIgE and nasal symptom).

OriginalsprogEngelsk
TidsskriftPharmacoepidemiology and Drug Safety
Vol/bind29
Udgave nummer11
Sider (fra-til)1423-1431
Antal sider9
ISSN1053-8569
DOI
StatusUdgivet - nov. 2020

Bibliografisk note

© 2020 John Wiley & Sons Ltd.

ID: 60929519