Forskning
Udskriv Udskriv
Switch language
Region Hovedstaden - en del af Københavns Universitetshospital
Udgivet

Calcium transport in male reproduction is possibly influenced by vitamin D and CaSR

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

DOI

  1. Hypophysectomy abolishes rhythms in rat thyroid hormones but not in the thyroid clock

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  2. Increased susceptibility to diet-induced obesity in GPRC6A receptor knockout mice

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  3. Interleukin-6 autoantibodies are involved in the pathogenesis of a subset of type 2 diabetes

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  4. Expression and localization of the progesterone receptor in mouse and human reproductive organs

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  1. Bilateral oophorectomy and rate of colorectal cancer: A prospective cohort study

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  2. Vitamin D supplementation improves fasting insulin levels and HDL cholesterol in infertile men

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  3. Severe hypocalcemia due to hypoparathyroidism associated with HIV: A case report

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

Vis graf over relationer

Vitamin D is important for gonadal function in rodents, and improvement of vitamin D status in men with low sperm counts increases live birth rate. Vitamin D is a regulator of transcellular calcium transport in the intestine and kidney and may influence the dramatic changes in the luminal calcium concentration in epididymis. Here, we show spatial expression in the male reproductive tract of vitamin D receptor (VDR)-regulated factors involved in calcium transport: transient receptor potential vanilloid 5/6 , sodium/calcium exchanger 1, plasma membrane calcium ATPase 1, calbindin D9k, calcium-sensing receptor (CaSR), and parathyroid hormone-related peptide (PTHrP) in mouse and human testis and epididymis. Testicular Casr expression was lower in Vdr ablated mice compared with controls. Moreover, expression levels of Casr and Pthrp were strongly correlated in both testis and epididymis and Pthrp was suppressed by 1,25(OH)2D3 in a spermatogonial cell line. The expression of CaSR in epididymis may be of greater importance than in the gonad in mice as germ cell-specific Casr deficient mice had no major reproductive phenotype, and coincubation with a CaSR-agonist had no effect on human sperm-oocyte binding. In humans, seminal calcium concentration between 5 and 10 mM was associated with a higher fraction of motile and morphologically normal sperm cells, and the seminal calcium concentration was not associated with serum calcium levels. In conclusion, VDR regulates CaSR and PTHrP, and both factors may be involved in the regulation of calcium transport in the male reproductive tract with possible implications for sperm function and storage.

OriginalsprogEngelsk
TidsskriftJournal of Endocrinology
Vol/bind251
Udgave nummer3
Sider (fra-til)207-222
Antal sider16
ISSN0022-0795
DOI
StatusUdgivet - 5 nov. 2021

ID: 68857074