Forskning
Udskriv Udskriv
Switch language
Region Hovedstaden - en del af Københavns Universitetshospital
Udgivet

Calcium electroporation for recurrent head and neck cancer: A clinical phase I study

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

DOI

  1. A systematic review of surgical treatment for supraglottic exercise-induced laryngeal obstruction

    Publikation: Bidrag til tidsskriftReviewForskningpeer review

  2. Progressive resistance training in head and neck cancer patients undergoing concomitant chemoradiotherapy

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  3. The true malignancy rate in 135 patients with preoperative diagnosis of a lateral neck cyst

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  1. 123I-MIBG for detection of subacute doxorubicin-induced cardiotoxicity in patients with malignant lymphoma

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  2. Electrochemotherapy in the head and neck area: an addition to the treatment armamentarium

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

Vis graf over relationer

Background: Calcium electroporation is a novel cancer treatment, which combines temporary cell permeability from electroporation with a high influx of calcium intracellularly resulting in cancer cell necrosis.

Methods: A phase I trial performing calcium electroporation on 6 patients suffering from recurrent head and neck cancer. In general anesthesia, intratumoral calcium injections were followed by electroporation. Safety was monitored by adverse events registration, serum Ca2+, ECG, and pain scores. Tumor response was measured on PET/MRI scans.

Results: Procedures were performed without complications. No serious adverse events, signs of hypercalcemia, or cardiac arrhythmias were observed. Two months post-treatment tumor responses on MRI: three partial responses, one stable disease, and two progression. Responses on PET: one partial metabolic disease, four with stable metabolic disease, and one not evaluable. One patient was without clinical evidence of disease after 12 months of observation.

Conclusion: Calcium electroporation is feasible and safe in head and neck tumors. Clinical responses were observed in three of six patients, warranting further studies.

Level of Evidence: Level 4.

OriginalsprogEngelsk
TidsskriftLaryngoscope Investigative Otolaryngology
Vol/bind4
Udgave nummer1
Sider (fra-til)49-56
Antal sider8
ISSN2378-8038
DOI
StatusUdgivet - feb. 2019

ID: 58435273