Calcitonin Gene-Related Peptide (CGRP) and Pituitary Adenylate Cyclase-Activating Polypeptide (PACAP) in Migraine Pathogenesis

Casper Emil Christensen, Messoud Ashina, Faisal Mohammad Amin*

*Corresponding author af dette arbejde

Abstract

Migraine is a prevalent and debilitating neurologic disorder. Advancements in understanding the underlying pathophysiological mechanisms are spearheading the effort to introduce disease-specific treatment options. In recent years this effort has largely focused on alteration of endogenous neuropeptide signaling, namely the peptides calcitonin gene-related peptide (CGRP) and pituitary adenylate cyclase-activating polypeptide (PACAP). Human studies into the pathophysiological underpinnings of CGRP and PACAP in migraine are manifold and here we review the works investigating these neuropeptides in patients suffering from migraine in order to elucidate the background for developing new treatment options for this vastly disabling disorder.

OriginalsprogEngelsk
Artikelnummer1189
TidsskriftPharmaceuticals (Basel, Switzerland)
Vol/bind15
Udgave nummer10
ISSN1424-8247
DOI
StatusUdgivet - 27 sep. 2022

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