CAG repeat length in androgen-receptor gene and reproductive variables in fertile and infertile men

Ewa Rajpert-De Meyts; Henrik Leffers; Jørgen H Petersen; Anne Grethe Andersen; Elisabeth Carlsen; Niels Jørgensen; Niels E Skakkebaek

doi:10.1016/s0140-6736(02)07280-x

CAG repeat length in androgen-receptor gene and reproductive variables in fertile and infertile men

Ewa Rajpert-De Meyts, Henrik Leffers, Jørgen H Petersen, Anne Grethe Andersen, Elisabeth Carlsen, Niels Jørgensen, Niels E Skakkebaek

Abstract

Several reports implicated a relation between the trinucleotide (CAG) repeat length in the androgen-receptor gene and male infertility, whereas others failed to find an association. We investigated the CAG repeat length in relation to sperm production and reproductive hormones in 119 infertile men and 110 men with proven fertility. We found no difference in the distribution of CAG repeat lengths between the groups and no association with reproductive parameters. This finding suggests that, within the normal range of 14-33 repeats, there is no biological link between the CAG repeat length and fertility. This lack of association was comfirmed by an analysis of the data from all previously published European studies (in total 674 infertile men and 660 controls).

Originalsprog	Engelsk
Tidsskrift	Lancet
Vol/bind	359
Udgave nummer	9300
Sider (fra-til)	44-6
Antal sider	3
ISSN	0140-6736
DOI	https://doi.org/10.1016/s0140-6736(02)07280-x
Status	Udgivet - 5 jan. 2002
Udgivet eksternt	Ja

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10.1016/s0140-6736(02)07280-x

Citationsformater

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title = "CAG repeat length in androgen-receptor gene and reproductive variables in fertile and infertile men",

abstract = "Several reports implicated a relation between the trinucleotide (CAG) repeat length in the androgen-receptor gene and male infertility, whereas others failed to find an association. We investigated the CAG repeat length in relation to sperm production and reproductive hormones in 119 infertile men and 110 men with proven fertility. We found no difference in the distribution of CAG repeat lengths between the groups and no association with reproductive parameters. This finding suggests that, within the normal range of 14-33 repeats, there is no biological link between the CAG repeat length and fertility. This lack of association was comfirmed by an analysis of the data from all previously published European studies (in total 674 infertile men and 660 controls).",

keywords = "Adolescent, Adult, Case-Control Studies, Denmark, Humans, Infertility, Male/genetics, Male, Receptors, Androgen/blood, Risk Factors, Sperm Count, Trinucleotide Repeats/genetics",

author = "{Rajpert-De Meyts}, Ewa and Henrik Leffers and Petersen, {J{\o}rgen H} and Andersen, {Anne Grethe} and Elisabeth Carlsen and Niels J{\o}rgensen and Skakkebaek, {Niels E}",

year = "2002",

month = jan,

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doi = "10.1016/s0140-6736(02)07280-x",

language = "English",

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pages = "44--6",

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TY - JOUR

T1 - CAG repeat length in androgen-receptor gene and reproductive variables in fertile and infertile men

AU - Rajpert-De Meyts, Ewa

AU - Leffers, Henrik

AU - Petersen, Jørgen H

AU - Andersen, Anne Grethe

AU - Carlsen, Elisabeth

AU - Jørgensen, Niels

AU - Skakkebaek, Niels E

PY - 2002/1/5

Y1 - 2002/1/5

N2 - Several reports implicated a relation between the trinucleotide (CAG) repeat length in the androgen-receptor gene and male infertility, whereas others failed to find an association. We investigated the CAG repeat length in relation to sperm production and reproductive hormones in 119 infertile men and 110 men with proven fertility. We found no difference in the distribution of CAG repeat lengths between the groups and no association with reproductive parameters. This finding suggests that, within the normal range of 14-33 repeats, there is no biological link between the CAG repeat length and fertility. This lack of association was comfirmed by an analysis of the data from all previously published European studies (in total 674 infertile men and 660 controls).

AB - Several reports implicated a relation between the trinucleotide (CAG) repeat length in the androgen-receptor gene and male infertility, whereas others failed to find an association. We investigated the CAG repeat length in relation to sperm production and reproductive hormones in 119 infertile men and 110 men with proven fertility. We found no difference in the distribution of CAG repeat lengths between the groups and no association with reproductive parameters. This finding suggests that, within the normal range of 14-33 repeats, there is no biological link between the CAG repeat length and fertility. This lack of association was comfirmed by an analysis of the data from all previously published European studies (in total 674 infertile men and 660 controls).

KW - Adolescent

KW - Adult

KW - Case-Control Studies

KW - Denmark

KW - Humans

KW - Infertility, Male/genetics

KW - Male

KW - Receptors, Androgen/blood

KW - Risk Factors

KW - Sperm Count

KW - Trinucleotide Repeats/genetics

U2 - 10.1016/s0140-6736(02)07280-x

DO - 10.1016/s0140-6736(02)07280-x

M3 - Journal article

C2 - 11809188

SN - 0140-6736

VL - 359

SP - 44

EP - 46

JO - Lancet

JF - Lancet

IS - 9300

ER -

CAG repeat length in androgen-receptor gene and reproductive variables in fertile and infertile men

Abstract

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