C-reactive protein levels and body mass index: elucidating direction of causation through reciprocal Mendelian randomization

N J Timpson; B G Nordestgaard; R M Harbord; J Zacho; T M Frayling; Anne  Tybjærg-Hansen; G Davey Smith

doi:10.1038/ijo.2010.137

C-reactive protein levels and body mass index: elucidating direction of causation through reciprocal Mendelian randomization

N J Timpson
, B G Nordestgaard
, R M Harbord
, J Zacho
, T M Frayling
, Anne Tybjærg-Hansen
, G Davey Smith

Afdeling for Klinisk Biokemi DIA

258 Citationer (Scopus)

Abstract

The assignment of direction and causality within networks of observational associations is problematic outside randomized control trials, and the presence of a causal relationship between body mass index (BMI) and C-reactive protein (CRP) is disputed.

Originalsprog	Engelsk
Tidsskrift	International Journal of Obesity
Vol/bind	35
Udgave nummer	2
Sider (fra-til)	300-8
Antal sider	9
ISSN	0307-0565
DOI	https://doi.org/10.1038/ijo.2010.137
Status	Udgivet - 1 feb. 2011

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10.1038/ijo.2010.137

Citationsformater

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title = "C-reactive protein levels and body mass index: elucidating direction of causation through reciprocal Mendelian randomization",

abstract = "The assignment of direction and causality within networks of observational associations is problematic outside randomized control trials, and the presence of a causal relationship between body mass index (BMI) and C-reactive protein (CRP) is disputed.",

keywords = "Adiposity, Adult, Aged, Aged, 80 and over, Biological Markers, Body Mass Index, C-Reactive Protein, Cross-Sectional Studies, Denmark, Female, Genetic Variation, Genotype, Humans, Male, Mendelian Randomization Analysis, Middle Aged, Obesity, Sex Factors, Young Adult",

author = "Timpson, \{N J\} and Nordestgaard, \{B G\} and Harbord, \{R M\} and J Zacho and Frayling, \{T M\} and Anne Tybj{\ae}rg-Hansen and Smith, \{G Davey\}",

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AU - Timpson, N J

AU - Nordestgaard, B G

AU - Harbord, R M

AU - Zacho, J

AU - Frayling, T M

AU - Tybjærg-Hansen, Anne

AU - Smith, G Davey

PY - 2011/2/1

Y1 - 2011/2/1

N2 - The assignment of direction and causality within networks of observational associations is problematic outside randomized control trials, and the presence of a causal relationship between body mass index (BMI) and C-reactive protein (CRP) is disputed.

AB - The assignment of direction and causality within networks of observational associations is problematic outside randomized control trials, and the presence of a causal relationship between body mass index (BMI) and C-reactive protein (CRP) is disputed.

KW - Adiposity

KW - Adult

KW - Aged

KW - Aged, 80 and over

KW - Biological Markers

KW - Body Mass Index

KW - C-Reactive Protein

KW - Cross-Sectional Studies

KW - Denmark

KW - Female

KW - Genetic Variation

KW - Genotype

KW - Humans

KW - Male

KW - Mendelian Randomization Analysis

KW - Middle Aged

KW - Obesity

KW - Sex Factors

KW - Young Adult

U2 - 10.1038/ijo.2010.137

DO - 10.1038/ijo.2010.137

M3 - Journal article

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JO - International Journal of Obesity

JF - International Journal of Obesity

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ER -

C-reactive protein levels and body mass index: elucidating direction of causation through reciprocal Mendelian randomization

Abstract

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