Forskning
Udskriv Udskriv
Switch language
Region Hovedstaden - en del af Københavns Universitetshospital
Udgivet

Burden and incidence of human papillomavirus-associated cancers and precancerous lesions in Denmark

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

DOI

  1. Estimates of prediabetes and undiagnosed type 2 diabetes in Denmark: The end of an epidemic or a diagnostic artefact?

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  2. A three-year national follow-up study on the development of community-level cancer rehabilitation in Denmark

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  1. The molecular profile of mucosal melanoma

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  2. Outcome in patients with isolated regional recurrence after primary radiotherapy for head and neck cancer

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  3. Development of depression in patients with oral cavity cancer: a systematic review

    Publikation: Bidrag til tidsskriftReviewForskningpeer review

Vis graf over relationer

AIM: The aim of the study was to investigate the incidence of human papillomavirus (HPV)-associated cancers in Denmark between 1978 and 2011, estimate the current absolute annual number (burden) of HPV-associated cancers (HPVaCa) and their precancerous lesions, and assess whether there is socioeconomic inequality in the risk of HPV-associated cancers.

METHODS: From four nationwide population-based registries, information was collected on HPVaCa diagnosed during 1978-2011 and age-standardised incidence rate for each site by calendar year and birth cohort was calculated. Furthermore, the current annual burden of HPVaCa and severe precancerous lesions was estimated. Incidence rate ratios and corresponding 95% confidence intervals for HPVaCa were calculated according to socioeconomic status.

RESULTS: The age-standardised incidence rate of HPV-associated cancers for the two sexes converged during the study period, and almost identical incidence rates were seen for women and men in the youngest birth cohorts. The current burden of HPV-associated lesions amounted to more than 5000 cases, the vast majority (85%) being severe precancerous lesions. The highest risk for HPV-associated cancers was associated with lower socioeconomic status. CONCLUSIONS THE BURDEN OF HPV-ASSOCIATED CANCERS AMONG MEN WILL LIKELY SURPASS THAT AMONG WOMEN IN THE NEAR FUTURE IF THE INCIDENCE TRENDS CONTINUE AS MANY OF THESE CANCERS AND THEIR PRECANCEROUS LESIONS ARE ASSOCIATED WITH HPV TYPE 16, A SUBSTANTIAL PROPORTION OF CASES ARE, IN THEORY, PREVENTABLE BY THE CURRENTLY AVAILABLE VACCINES.

OriginalsprogEngelsk
TidsskriftScandinavian Journal of Public Health
Vol/bind44
Udgave nummer6
Sider (fra-til)551-9
Antal sider9
ISSN1403-4948
DOI
StatusUdgivet - aug. 2016

ID: 49567872