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Region Hovedstaden - en del af Københavns Universitetshospital
Udgivet

Building the mammalian testis: origins, differentiation, and assembly of the component cell populations

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DOI

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  2. Surgical Management of Undescended Testis - Timetable and Outcome: A Debate

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  4. ERG promotes the maintenance of hematopoietic stem cells by restricting their differentiation

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  5. Loss of TET2 in hematopoietic cells leads to DNA hypermethylation of active enhancers and induction of leukemogenesis

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  1. Juvenile Male Rats Exposed to a Low-Dose Mixture of Twenty-Seven Environmental Chemicals Display Adverse Health Effects

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  2. Validation of endogenous normalizing genes for expression analyses in adult human testis and germ cell neoplasms

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  3. SOX9 regulates microRNA miR-202-5p/3p expression during mouse testis differentiation

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

Vis graf over relationer
Development of testes in the mammalian embryo requires the formation and assembly of several cell types that allow these organs to achieve their roles in male reproduction and endocrine regulation. Testis development is unusual in that several cell types such as Sertoli, Leydig, and spermatogonial cells arise from bipotential precursors present in the precursor tissue, the genital ridge. These cell types do not differentiate independently but depend on signals from Sertoli cells that differentiate under the influence of transcription factors SRY and SOX9. While these steps are becoming better understood, the origins and roles of many testicular cell types and structures-including peritubular myoid cells, the tunica albuginea, the arterial and venous blood vasculature, lymphatic vessels, macrophages, and nerve cells-have remained unclear. This review synthesizes current knowledge of how the architecture of the testis unfolds and highlights the questions that remain to be explored, thus providing a roadmap for future studies that may help illuminate the causes of XY disorders of sex development, infertility, and testicular cancers.
OriginalsprogEngelsk
TidsskriftGenes & Development
Vol/bind27
Udgave nummer22
Sider (fra-til)2409-26
Antal sider18
ISSN0890-9369
DOI
StatusUdgivet - 15 nov. 2013

ID: 41682288