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Region Hovedstaden - en del af Københavns Universitetshospital
Udgivet

Broadly neutralizing antibodies targeted to mucin-type carbohydrate epitopes of human immunodeficiency virus.

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Vis graf over relationer
The cancer-related mucin-type carbohydrate neoantigen Tn was found on gp160 and gp120 of human immunodeficiency virus (HIV). Immunoglobulin G (IgG) and IgM monoclonal antibodies (MAbs) against Tn neutralized infection with cell-free virus and blocked fusion between HIV-infected and uninfected cells. This inhibition was found in infection of both lymphocytic cells and monocytoid cells. Viruses tested included six HIV-1 and five HIV-2 isolates propagated in different cells, as well as infectious plasma from AIDS patients. The antiviral effect of anti-Tn MAbs occurred by specific binding of the MAb to the virus; this binding was inhibitable by pure Tn antigen, and indications were found that this inhibition occurred at a pre-entry step. Boosting the naturally occurring low-titer anti-Tn activity may be of prophylactic value, as suggested by the in vitro neutralization found in this study.
Bidragets oversatte titelBroadly neutralizing antibodies targeted to mucin-type carbohydrate epitopes of human immunodeficiency virus.
OriginalsprogEngelsk
TidsskriftJournal of Virology
Vol/bind65
Udgave nummer12
Sider (fra-til)6461-6467
Antal sider7
ISSN0022-538X
StatusUdgivet - 1991

ID: 32506217