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Region Hovedstaden - en del af Københavns Universitetshospital
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Breast cancer risk factors and their effects on survival: a Mendelian randomisation study

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

DOI

  1. Common Susceptibility Loci for Male Breast Cancer

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  2. Breast cancer risk factors and survival by tumor subtype: Pooled analyses from the breast cancer association consortium

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  3. Breast Cancer Risk Genes - Association Analysis in More than 113,000 Women

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  • Maria Escala-Garcia
  • Anna Morra
  • Sander Canisius
  • Jenny Chang-Claude
  • Siddhartha Kar
  • Wei Zheng
  • Stig E Bojesen
  • Doug Easton
  • Paul D P Pharoah
  • Marjanka K Schmidt
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BACKGROUND: Observational studies have investigated the association of risk factors with breast cancer prognosis. However, the results have been conflicting and it has been challenging to establish causality due to potential residual confounding. Using a Mendelian randomisation (MR) approach, we aimed to examine the potential causal association between breast cancer-specific survival and nine established risk factors for breast cancer: alcohol consumption, body mass index, height, physical activity, mammographic density, age at menarche or menopause, smoking, and type 2 diabetes mellitus (T2DM).

METHODS: We conducted a two-sample MR analysis on data from the Breast Cancer Association Consortium (BCAC) and risk factor summary estimates from the GWAS Catalog. The BCAC data included 86,627 female patients of European ancestry with 7054 breast cancer-specific deaths during 15 years of follow-up. Of these, 59,378 were estrogen receptor (ER)-positive and 13,692 were ER-negative breast cancer patients. For the significant association, we used sensitivity analyses and a multivariable MR model. All risk factor associations were also examined in a model adjusted by other prognostic factors.

RESULTS: Increased genetic liability to T2DM was significantly associated with worse breast cancer-specific survival (hazard ratio [HR] = 1.10, 95% confidence interval [CI] = 1.03-1.17, P value [P] = 0.003). There were no significant associations after multiple testing correction for any of the risk factors in the ER-status subtypes. For the reported significant association with T2DM, the sensitivity analyses did not show evidence for violation of the MR assumptions nor that the association was due to increased BMI. The association remained significant when adjusting by other prognostic factors.

CONCLUSIONS: This extensive MR analysis suggests that T2DM may be causally associated with worse breast cancer-specific survival and therefore that treating T2DM may improve prognosis.

OriginalsprogEngelsk
Artikelnummer327
TidsskriftBMC Medicine
Vol/bind18
Udgave nummer1
Sider (fra-til)327
ISSN1741-7015
DOI
StatusUdgivet - 17 nov. 2020

ID: 61973801