Breast cancer after bilateral risk-reducing mastectomy

A-B Skytte; Dorthe Gylling Crüger; Mette Gerster; Anne-Vibeke Lænkholm; Charlotte Lanng; Karen Brøndum-Nielsen; M K Andersen; Lone E. M. Sunde; Steen Kølvraa; Anne-Marie Axø Gerdes

doi:10.1111/j.1399-0004.2010.01604.x

Breast cancer after bilateral risk-reducing mastectomy

A-B Skytte, Dorthe Gylling Crüger, Mette Gerster, Anne-Vibeke Lænkholm, Charlotte Lanng, Karen Brøndum-Nielsen, M K Andersen, Lone E. M. Sunde, Steen Kølvraa, Anne-Marie Axø Gerdes

53 Citationer (Scopus)

Abstract

This study aims to evaluate the incidence of breast cancer after risk-reducing mastectomy (RRM) in healthy BRCA mutation carriers. This study is a long-term follow-up of 307 BRCA mutation carriers of whom 96 chose RRM. None of the study participants had a previous history of breast or ovarian cancer nor had they undergone RRM or risk-reducing bilateral salpingo-oophorectomy (BSO) prior to the time of BRCA testing. The annual incidence of post-mastectomy breast cancer was 0.8% compared with 1.7% in the non-operated group. Implications of these findings in relation to genetic counseling and future management are discussed.

Originalsprog	Engelsk
Tidsskrift	Clinical Genetics
Vol/bind	79
Udgave nummer	5
Sider (fra-til)	431-7
Antal sider	7
ISSN	0009-9163
DOI	https://doi.org/10.1111/j.1399-0004.2010.01604.x
Status	Udgivet - 2011

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10.1111/j.1399-0004.2010.01604.x

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title = "Breast cancer after bilateral risk-reducing mastectomy",

abstract = "This study aims to evaluate the incidence of breast cancer after risk-reducing mastectomy (RRM) in healthy BRCA mutation carriers. This study is a long-term follow-up of 307 BRCA mutation carriers of whom 96 chose RRM. None of the study participants had a previous history of breast or ovarian cancer nor had they undergone RRM or risk-reducing bilateral salpingo-oophorectomy (BSO) prior to the time of BRCA testing. The annual incidence of post-mastectomy breast cancer was 0.8% compared with 1.7% in the non-operated group. Implications of these findings in relation to genetic counseling and future management are discussed.",

keywords = "Adult, Aged, Aged, 80 and over, Breast Neoplasms, Female, Genes, BRCA1, Genes, BRCA2, Humans, Mastectomy, Middle Aged, Mutation, Risk Reduction Behavior, Young Adult",

author = "A-B Skytte and Cr{\"u}ger, {Dorthe Gylling} and Mette Gerster and Anne-Vibeke L{\ae}nkholm and Charlotte Lanng and Karen Br{\o}ndum-Nielsen and Andersen, {M K} and Sunde, {Lone E. M.} and Steen K{\o}lvraa and Gerdes, {Anne-Marie Ax{\o}}",

note = "{\textcopyright} 2011 John Wiley & Sons A/S.",

year = "2011",

doi = "10.1111/j.1399-0004.2010.01604.x",

language = "English",

volume = "79",

pages = "431--7",

journal = "Clinical Genetics",

issn = "0009-9163",

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TY - JOUR

T1 - Breast cancer after bilateral risk-reducing mastectomy

AU - Skytte, A-B

AU - Crüger, Dorthe Gylling

AU - Gerster, Mette

AU - Lænkholm, Anne-Vibeke

AU - Lanng, Charlotte

AU - Brøndum-Nielsen, Karen

AU - Andersen, M K

AU - Sunde, Lone E. M.

AU - Kølvraa, Steen

AU - Gerdes, Anne-Marie Axø

PY - 2011

Y1 - 2011

N2 - This study aims to evaluate the incidence of breast cancer after risk-reducing mastectomy (RRM) in healthy BRCA mutation carriers. This study is a long-term follow-up of 307 BRCA mutation carriers of whom 96 chose RRM. None of the study participants had a previous history of breast or ovarian cancer nor had they undergone RRM or risk-reducing bilateral salpingo-oophorectomy (BSO) prior to the time of BRCA testing. The annual incidence of post-mastectomy breast cancer was 0.8% compared with 1.7% in the non-operated group. Implications of these findings in relation to genetic counseling and future management are discussed.

AB - This study aims to evaluate the incidence of breast cancer after risk-reducing mastectomy (RRM) in healthy BRCA mutation carriers. This study is a long-term follow-up of 307 BRCA mutation carriers of whom 96 chose RRM. None of the study participants had a previous history of breast or ovarian cancer nor had they undergone RRM or risk-reducing bilateral salpingo-oophorectomy (BSO) prior to the time of BRCA testing. The annual incidence of post-mastectomy breast cancer was 0.8% compared with 1.7% in the non-operated group. Implications of these findings in relation to genetic counseling and future management are discussed.

KW - Adult

KW - Aged

KW - Aged, 80 and over

KW - Breast Neoplasms

KW - Female

KW - Genes, BRCA1

KW - Genes, BRCA2

KW - Humans

KW - Mastectomy

KW - Middle Aged

KW - Mutation

KW - Risk Reduction Behavior

KW - Young Adult

U2 - 10.1111/j.1399-0004.2010.01604.x

DO - 10.1111/j.1399-0004.2010.01604.x

M3 - Journal article

C2 - 21199491

SN - 0009-9163

VL - 79

SP - 431

EP - 437

JO - Clinical Genetics

JF - Clinical Genetics

IS - 5

ER -

Breast cancer after bilateral risk-reducing mastectomy

Abstract

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