Brazilian validation of the european organisation for research and treatment of cancer (Eortc) quality of life group (qlg) computerised adaptive tests (cat) core

Gustavo Nader Marta*, Tomás Y.T. de Souza, Alice R.N. de Souza e Silva, Ana Paula A. Pereira, David R. Ferreira Neto, Rie N. Asso, Fabiana A.M. Degrande, Guilherme Nader-Marta, Maurício F. da Silva, Rafael Gadia, Samir A. Hanna, Bernhard Holzner, Everardo D. Saad, Morten Aagaard Petersen

*Corresponding author af dette arbejde
1 Citationer (Scopus)

Abstract

Background: This study aimed to validate the Brazilian version of EORTC CAT Core and compare the Brazilian results with those from the original European EORTC CAT Core validation study. Methods: After validated translation, 168 cancer patients from Brazil receiving radiation therapy with or without chemotherapy was assessed. Translated EORTC CAT Core and all QLQ-C30 items were administered to patients using CHES (Computer-Based Health Evaluation System) before (T0) and after (T1) treatment initiation. The association between QLQ-C30 and CAT scores and ceiling/floor effects were estimated. Based on estimates of relative validity (cross-sectional, known-group differences and changes over time), relative sample-size requirements for CAT compared to QLQ-C30 were estimated. Results: Correlation coefficients between CAT and QLQ-C30 domains ranged from 0.63 to 0.93; except for dyspnoea, all coefficients were >0.82 (corresponding figures were 0.81–0.93 in the European study). On average across domains, floor/ceiling was reduced by 10% using CAT (9% in the European study) corresponding to a relative reduction of 32% (37% in the European study). Analyses of known-group validity and responsiveness indicated that, on average across domains, the sample-size requirements may be reduced by 17% using CAT rather than QLQ-C30, without loss of power (28% in the European study). The Brazilian sample had less symptom/quality of life impairment than the European sample, which likely explains the lower sample-size reduction using CAT when comparing with the European sample. Conclusions: The results in the Brazilian cohort were generally similar to those from the European sample and confirm the validity and usefulness of the EORTC CAT Core.

OriginalsprogEngelsk
TidsskriftCurrent Oncology
Vol/bind28
Udgave nummer5
Sider (fra-til)3373-3383
Antal sider11
ISSN1198-0052
DOI
StatusUdgivet - okt. 2021

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